早期成人型卵巢颗粒细胞瘤复发相关因素分析北大核心CSCD

目的探讨国际妇产科联盟(FIGO)(2014版)Ⅰ期成人型卵巢颗粒细胞瘤复发的相关高危因素。方法回顾性分析首都医科大学附属北京朝阳医院及中国医学科学院北京协和医院1995年1月至2010年1月收治的FIGOⅠ期成人型卵巢颗粒细胞瘤。分析患者临床及病理相关因素与肿瘤复发的关系。结果研究共纳入18例FIGOⅠ期成人型卵巢颗粒细胞瘤患者,患者中位年龄为43岁(31~69岁)。初始治疗中7例行单纯肿瘤剥除/单侧附件切除术,8例行子宫双附件切除术,3例行卵巢肿瘤全面分期术。患者术后5年和10年总生存率分别为94.4%和83.3%。共6例患者复发,中位复发时间为76个月。肿瘤直径>10cm、术中瘤体破裂是患者近期复发(<5年)的高危因素。低分化、术中瘤体破裂、高核分裂象(≥4/10HPF)是患者远期复发(≥5年)的高危因素。结论早期成人型卵巢颗粒细胞瘤整体预后好,高核分裂象、术中瘤体破裂可能是早期卵巢颗粒细胞瘤复发的潜在高危因素。

Analysis of the related factors for the recurrence of early adult granulosa cell tumor of the ovary

Objective To investigate the high-risk factors related to the recurrence of FIGO stage I adult granulosa cell tumor of the ovary.Methods A retrospective analysis was performed in patients with the FIGO stage I adult granulosa cell tumor of the ovary admitted to Beijing Chaoyang Hospital of Capital Medical University and PUMCH from January1995 to January 2010.The relationship between clinical,pathological factors and tumor recurrence was analyzed.Results The study included 18 patients with FIGO stage I adult granulosa cell tumor of the ovary.The median age of the patients was 43(31-69 years old).During the initial treatment,7 patients underwent simple tumor removal/unilateral adnexectomy,8 underwent hysterectomy with double appendages,and 3 underwent comprehensive surgical staging of ovarian tumors.The total 5-year and 10-year survival rates were 94.4%and 83.3%,respectively.A total of 6 patients relapsed,with a median recurrence time of 76 months.The high-risk factors of recent recurrence(within 5 years)included tumor diameter>10 cm and tumor rupture during surgery.The high-risk factors of long-term recurrence(≥5 years)included poor differentiation,tumor rupture,and high mitotic count(≥4/10 HPF).Conclusion The prognosis of early adult granulosa cell tumor of the ovary.High mitotic count and tumor rupture during surgery may be potential highrisk factors for the recurrence of early granulosa cell tumor of the ovary.