| 白屈菜碱的药理作用研究进展 |
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| 引用本文： | 邹翔,王雨蒙,王嘉琪,龙丽莉,王超,刘影,盛洁静,曲中原.白屈菜碱的药理作用研究进展[J].现代药物与临床,2014,29(11):1326-1330. |
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| 作者姓名： | 邹翔 王雨蒙 王嘉琪 龙丽莉 王超 刘影 盛洁静 曲中原 |
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| 作者单位： | 哈尔滨商业大学 药物研究所 博士后科研工作站, 黑龙江 哈尔滨 150076;哈尔滨商业大学 抗肿瘤天然药物教育部工程研究中心, 黑龙江 哈尔滨 150076;哈尔滨商业大学 抗肿瘤天然药物教育部工程研究中心, 黑龙江 哈尔滨 150076;齐齐哈尔富拉尔基区中医医院, 黑龙江 齐齐哈尔 161041;哈尔滨商业大学 抗肿瘤天然药物教育部工程研究中心, 黑龙江 哈尔滨 150076;哈尔滨商业大学 抗肿瘤天然药物教育部工程研究中心, 黑龙江 哈尔滨 150076;哈尔滨商业大学 药学院, 黑龙江 哈尔滨 150076;哈尔滨商业大学 药学院, 黑龙江 哈尔滨 150076 |
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| 基金项目： | 国家自然科学基金资助项目(81102858);中国博士后科学基金资助项目(2013M531060);黑龙江省自然科学基金资助项目(D200817);黑龙江省博士后科研基金项目(LBH-Z11103);黑龙江省教育厅骨干教师项目(1154G35) |
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| 摘 要： | 白屈菜碱是白屈菜Chelidonium majus的主要活性成分之一,属于苯并菲啶类生物碱,现作为止痛药应用于临床。随着对白屈菜碱药理作用的深入研究发现,其具有抗肿瘤、镇痛、抗菌、解痉等多种药理作用,且其抗肿瘤作用越来越受到关注。对近年来白屈菜碱药理作用的国内外研究进展做以综述,为其进一步研究与应用提供理论依据。
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| 关 键 词： | 白屈菜 白屈菜碱 药理作用 作用机制 |
| 收稿时间： | 7/3/2014 12:00:00 AM |
Research progress on pharmacological activities of chelidonine |
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| ZOU Xiang,WANG Yu-meng,WANG Jia-qi,LONG Li-li,WANG Chao,LIU Ying,SHENG Jie-jing and QU Zhong-yuan.Research progress on pharmacological activities of chelidonine[J].Drugs & Clinic,2014,29(11):1326-1330. |
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| Authors: | ZOU Xiang WANG Yu-meng WANG Jia-qi LONG Li-li WANG Chao LIU Ying SHENG Jie-jing and QU Zhong-yuan |
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| Affiliation: | Post Doctoral Research Center, Institute of Materia Medica, Harbin University of Commarce, Harbin 150076, China;Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commarce, Harbin 150076, China;Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commarce, Harbin 150076, China;Qiqihar Fulaerji District Hospital of Traditional Chinese Medicine, Qiqihar 161041, China;Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commarce, Harbin 150076, China;Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commarce, Harbin 150076, China;College of Pharmacy, Harbin University of Commerce, Harbin 150076, China;College of Pharmacy, Harbin University of Commerce, Harbin 150076, China |
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| Abstract: | Chelidonine, a benzophen anthridine alkaloid, is one of the main effective constituents of Chelidonium majus, which is applied as a painkiller in clinical treatment. The further studies on the pharmacological activities in recent years have demonstrated that chelidonine plays a role in antitumor, analgesic, antibacterial, spasmolysis activities, etc. And the antitumor activity is paid more and more attention. In this paper, research progress on pharmacological activities and mechanisms of chelidonine home and abroad in recent years are reviewed, which could provide a theoretical basis for the further study and application of C. majus. |
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| Keywords: | Chelidonium majus L chelidonine pharmacological activities mechanism of action |
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