降钙素对正常成年雄性大鼠骨重建过程的影响

目的 在体研究降钙素对成年雄性大鼠松骨重建过程的影响，并分析其影响机制。方法 １２只大鼠平均分成对照组和降钙素组，后皮内注射鳗鱼降钙素１Ｕ／１００ｇ／日，连续２日。７日后取第４、５腰椎，行不脱钙骨组织切片，骨组织形态计量学分析，方差分析比较两组结果。结果 骨吸收陷窝表面、活性吸收表面、破骨细胞平均细胞核数，降钙素组明显小于对照组。类骨质表面、类骨质相对体积、类骨质厚度，降钙素组明显小于对照组，成

Effect of calcitonin on bone remodeling of adult male Wistar rat

Objective\ The effect of calcitonin on bone remodeling of adult male Wistar rat was observed and the mechanism was analyzed.Methods\ Twelve rats were distributed randomly to control and calcitonin groups.The rats in calcitonin group were administered elatonin(1U/100g/day,2days).The fourth and fifth lumbar vertebral bodies were undecalcified and analyzed by histomorphometry.T test was used to analyze the differences between the two groups.Results The eroded surface,active resorptive surface,nuclear number of osteoclasts in calcitonin group were less than in control group.The osteoid surface,osteoid volume,osteoid thickness in calcitonin group were less than in control group.There was significant difference in osteoblast appearance between calcitonin and control groups.There is no difference of trabecular volume between calcitonin and control group. Conclusion For normal adult male rat,calcitonin depresses the osteoclastic resorption obviously through reducing the number of active resorptive surface and depressing osteoclastic activity;on the other hand,calcitonin depresses the osteoid producing activity of osteoblasts by indirectly affecting the coupling process between resorption and formation.Calcitonin administered in short did not affect the bone volume.