肥胖危险因素与血清瘦素的相关性研究

目的　探讨瘦素 (leptin ,LP)与肥胖、体重指数、性别、胰岛素、血糖、血脂及 2型糖尿病的关系。方法　 6 0例肥胖与 5 0例非肥胖受试者禁食 1 0h ,于清晨排大、小便后精确测量其身高、体重 ,空腹测血瘦素、血糖、胰岛素、总胆固醇 (totalcholestero ,Tch)、甘油三酯 (triglycerides,TG)、低密度脂蛋白胆固醇 (lowdensitylipoproteincholestero ,LDL c)、高密度脂蛋白胆固醇 (highdensitylipoproteincholestero ,HDL c)。将肥胖组与非肥胖组分别根据性别及是否有 2型糖尿病进行两次分组 ,对瘦素及其他各参数作比较分析。结果　 (1 )肥胖组瘦素均较非肥胖组显著增高 ;(2 )女性瘦素水平显著高于男性 ;(3)肥胖组空腹胰岛素 (fastinginsulin ,FINS)水平显著高于非肥胖组 ,女性显著高于男性 ,血脂Tch、TG、LDL c水平肥胖组显著高于非肥胖组 ,HDL c水平肥胖组低于非肥胖组 ,肥胖组与非肥胖组空腹血糖水平无差异性 ;(4)肥胖组、非肥胖组中 2型糖尿病与非 2型糖尿病之间的瘦素水平、胰岛素水平均无显著差异性。结论　瘦素水平与肥胖关系密切 ,瘦素与体重指数 (bodymassindex ,BMI)呈正相关 (P <0 .0 1 ) ;女性瘦素水平显著高于男性 ,LP与性别有相关性 (P <0 .0 5 ) ;LP与胰岛素 (P <0 .0 1 )、Tch(P <0 .0 5 )、

Association of Serum Leptin with Risk Factors of Obesity

Objective To explore the relationship between serum leptin levels and obesity,body mass index(BMI),sex,insulin concentrations,plasma glucose,serum lipid and Type 2 diabetes.Methods 60 obese patients and 50 non obese individuals were attended in this study.Height,weight,fasting serum leptin,plasma glucose,plasma insulin,trilyceride(TG),serum total cholesterol(Tch),LDL c,HDL c were measured.Both the obese and in non obese groups all were divided into two groups twice according to sex and individuals with or without Type 2 diabetes.The correlation between leptin and other parameters were analysed.Results (1) The serum leptin levels were significantly higher in obese group than in non obese group.(2) The serum leptin levels were significantly higher women than is higher men.(3) The levels of fasting insulin were significantly higher in obese group and in non obese group,women in higher than men.The serum lipid levels of Tch?TG?LDL c were all higher in obese group than in non obese group,but HDL c levels were higher in non obese group than in obese group.The difference of plasma glucose levels between obese group and non obese group was not found.(4) The serum leptin level was less closely assotiated between patients with type 2 diabetes and without type 2 diabetes both in obese group and non obese group.Conclusion The serum leptin level was highly related to obesity and sex( P <0.01).The positive correlations were observed between leptin level and BMI( P <0.01),FINS( P <0.01),Tch( P <0.05),TG( P <0.05),and LDL c( P <0.05).Serum leptin level was negatively correlated with HDL c( P <0.05),but not correlated to blood glucose level and type 2 diabetes.