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| COX-1在卵巢癌组织中的表达及其意义 | |
| 引用本文： | 吴琼,卞丽红,胡晨明,杨瑛,李亚里.COX-1在卵巢癌组织中的表达及其意义[J].军事医学科学院院刊,2010,34(1):58-60. |
| 作者姓名： | 吴琼 卞丽红 胡晨明 杨瑛 李亚里 |
| 作者单位： | 1. 解放军307医院妇科,北京,100071;解放军总医院妇产科,北京,100853 2. 解放军307医院妇科,北京,100071 3. 解放军总医院妇产科,北京,100853 |
| 摘 要： | 目的探讨环氧化酶-1（COX-1）在卵巢癌组织中的表达及其意义。方法应用免疫组化SP法检测37例卵巢癌和31例卵巢囊肿组织中COX-1和CA125蛋白的表达;应用ELISA法检测40例卵巢癌和31例卵巢囊肿以及60例正常体检者血清中COX-1和CA125的浓度。结果COX-1、CA125在卵巢癌组织的表达率分别为78%和57%,在卵巢囊肿的阳性表达率仅为7%和3%;卵巢癌患者血清COX-1、CA125的阳性率分别为65%和93%。结论COX-1蛋白表达可作为卵巢癌的辅助诊断指标。 |
| 关 键 词： | COX-1 卵巢癌 蛋白表达 |
Expression of cyclooxygenase-1 in ovarian cancer and its significance |
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| WU Qiong,BIAN Li-hong,HU Chen-ming,YANG Ying,LI Yali.Expression of cyclooxygenase-1 in ovarian cancer and its significance[J].Bulletin of the Academy of Military Medical Sciences,2010,34(1):58-60. | |
| Authors: | WU Qiong BIAN Li-hong HU Chen-ming YANG Ying LI Yali |
| Affiliation: | 1.Department of Gynecology/a>;Hospital 307 of Chinese PLA/a>;Beijing 100071/a>;China/a>;2.Department of Gynecology and Obstetrics/a>;Chinese PLA General Hospital/a>;Beijing 100853/a>;China |
| Abstract: | Objective To explore the expression of cyclooxygenase-1 in ovarian cancer and its significance.Methods Expression of COX-1 and CA125 was detected by immunohistochemistry in 37 cases of ovarian cancer and 31 cases of ovarian cyst.The serum level of COX-1 and CA125 was tested in 40 cases of ovarian cancer and 31 cases of ovarian cyst and 60 healthy volunteers by ELISA.Results The positive expression of COX-1 and CA125 was 78% and 57% in ovarian cancer and 3% and 7% in ovarian cyst,respectively.The expression ... |
| Keywords: | cyclooxygenase-1 ovarian cancer protein expression |
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