人附睾蛋白4与溶血磷脂酸联合检测对子宫内膜癌的临床诊断价值分析

目的：探讨血清人附睾蛋白4（HE4）和溶血磷脂酸（LPA）联合检测对子宫内膜癌的诊断价值。方法采用酶联免疫吸附法和电化学发光法分别检测子宫内膜癌患者、子宫内膜异位症患者、功能失调性子宫出血患者及健康者血清 HE4和血浆 LPA水平，比较各研究组 HE4和 LPA水平及阳性率，分析 HE4、LPA单项及联合检测对子宫内膜癌的诊断效能。结果子宫内膜癌组 HE4、LPA水平较其他3组明显升高（P＜0．05）；HE4单项检测诊断子宫内膜癌的灵敏度为48．58％、特异度为95．74％，LPA 单项检测的诊断灵敏度为68．96％、特异度为87．23％，二者联合检测的诊断灵敏度为75．86％、特异度为87．23％，联合检测的诊断灵敏度较 LPA、HE4单项增高（P＜0．05）。结论 HE4和 LPA联合检测对子宫内膜癌的诊断效能优于二者单项检测。

Clinical values of combined detection of HE4 and LPA in diagnosis of endometrial carcinoma

Objective To investigate the diagnostic value of combined detection of human epididymis proteins 4 （HE4）and lysophosphatidic acid LPA for endometrial carcinoma.Methods Enzyme linked immunosorbent assay and electrochemiluminescence were used for the detection of serum HE4 and plasma LPA in healthy subjects and three patient groups,including endometrial cancer,endometriosis uterine and dysfunctional uterine bleeding.The lev-els and positive rates of serum HE4 and plasma LPA were compared between the four groups.The diagnostic per-formance of HE4,LPA and combined detection in endometrial cancer were analyzed.Results The levels of HE4 and LPA in endometrial cancer patients were obviously higher than the other three groups （P＆lt;0.05）.The diagnostic sensitivities of HE4 and LPA in diagnosis of endometrial cancer were 48.58% and 68.96% respectively,and the spe-cificities were 95.74% and 87.23% respectively.The specificity of combined detection of HE4 and LPA was 87.23%,and the sensitivity was 75.86%,which was higher than individual detection （P＆lt;0.05）.Conclusion The diagnostic value of combined detection of serum HE4 and LPA could be higher than individual detection for the diag-nosis of endometrial cancer.