降血脂药非诺贝特的绿色合成

以一水合硫酸氢钠为催化剂，二甲苯为带水剂，对非诺贝特酸与异丙醇的酯化反应进行了研究，考察了醇酸摩尔比、催化剂用量、带水剂用量等因素对非诺贝特产率的影响。结果表明：硫酸氢钠有着良好的催化活性，在非诺贝特酸用量0．1 mol， n（异丙醇）：n（非诺贝特酸）＝3．5：1，催化剂一水合硫酸氢钠用量3．5 g，二甲苯40 mL，反应时间3 h的条件下，非诺贝特产率可达88．6％，催化剂重复使用5次仍保持较高的活性，其结构经IR确证。

Green Synthesis of Hypolipidemic Drug Fenofibrate

The esterification of fenofibrate acid with isopropyl alcohol was studied with sodium bisulfate as catalyst and dimethylbenzene as water carrying agents.The effects of different factors such as mole ratio of reactants, catalyst dosage and amount of carrying agent on the yield of fenofibrate were investigated.The experimental results showed that sodium bisulfate monohydrate exhibited excellently catalytic activity.The optimum reaction conditions were found as follows：0.1 mol fenofibrate acid, mole ratio of isopropyl alcohol to fenofibrate acid was 3.5：1, the weight of the catalyst was 3.5 g, 40 mL dimethylbenzene, and refluxing reaction time was 30 min.Under these conditions, the yield of fenofibrate was up to 88.6%.The catalyst could be repeatedly used for five times without lossing its catalytic activity.The structure was characterized by IR.