| 松果菊苷改善SAM-P/8小鼠学习记忆能力作用机制初探 |
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| 引用本文： | 田枫,张阔,康爱君,姜勇,周淑佩,郑振辉.松果菊苷改善SAM-P/8小鼠学习记忆能力作用机制初探[J].实验动物科学,2006,23(2):14-15. |
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| 作者姓名： | 田枫 张阔 康爱君 姜勇 周淑佩 郑振辉 |
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| 作者单位： | 1. 北京大学医学部实验动物科学部,北京,100083
2. 北京大学现代中医药研究中心,北京,100083 |
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| 摘 要： | 目的探讨松果菊苷对SAM-P/8小鼠学习记忆能力的影响。方法以SAM-P/8小鼠为对象,给予松果菊苷连续灌胃30d,用化学比色试剂盒法测定脑组织总蛋白含量、总抗氧化能力和乙酰胆碱酯酶活性,用放免法测定血清中IL-2含量。结果松果菊苷能显著提高脑组织总蛋白含量、总抗氧化能力、降低乙酰胆碱酯酶活性及血清中IL-2含量。结论松果菊苷可能通过降低SAM-P/8小鼠脑组织氧化损伤改善其学习记忆能力。
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| 关 键 词： | 松果菊苷 快速老化模型小鼠 学习记忆 |
| 文章编号： | 1006-6179(2006)02-0014-02 |
| 收稿时间： | 2006-06-25 |
| 修稿时间： | 2005年11月1日 |
The Effect and Mechanism of Echinacoside on SAM-P/8's Learning and Memory Ability |
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| TIAN Feng,ZHANG Kuo,KANG Ai-jun,JIANG Yong,ZHOU Shu-pei,ZHENG Zhen-hui.The Effect and Mechanism of Echinacoside on SAM-P/8's Learning and Memory Ability[J].Shiyan Dongwu Kexue,2006,23(2):14-15. |
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| Authors: | TIAN Feng ZHANG Kuo KANG Ai-jun JIANG Yong ZHOU Shu-pei ZHENG Zhen-hui |
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| Abstract: | Objective To explore the effect and mechanism of Echinacoside on SAM-P/8's learning and memory ability.Methods SAM-P/8 mice were fed Echinacoside for 30 days continuously.Total protein,total antioxdative ability and acetylcholine of brain were detected by chemic kits.And the IL-2 of serum was examined by radio-immuno assay.Results The data shows that Echinacoside can improve total protein,total antioxdative ability and reduce acetylcholine as well as IL-2.Conclusion Echinacoside can increase the learning and memory ability of SAM-P/8,which may be related to reducing oxidative damage of the brain. |
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| Keywords: | Echinacoside Senescence-accelerated mouse Learning and memory ability |
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