槐定碱和氧化槐定碱的抗心律失常作用

目的；研究氧化槐定碱和槐定碱对试验性心律失掌上作用以及对心肌生理我的影响。方法：应用各种心律失常模型观察药物对实验性心律失常的作用；离体心肌实验法观察药物对心房生理特性的影响。结果：Ｏｘｙ５００ｍｇ．ｋｇ＾－１ｉｖ对抗乌头碱，哇巴因和结扎冠状动脉左前降支诱发的室性心率失常，使室性异位搏动数减少，室速持续时间缩短，室颤的发生率由７５％减少到１２．５％。

Anti-arrhythmic effects of sophoridine and oxysophoridine.

AIM: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties. METHODS: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. RESULTS: Oxy 500 mg.kg-1 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 mg.kg-1 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 mg.kg-1 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy. CONCLUSION: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose.