| 肝素对患感染性疾病的新生儿组织因子途径抑制物影响的观察 |
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| 引用本文： | 李晓静,蔡晓燕,李晓辉,包承鑫,周敏,李晋蜀,李丹,周开宇.肝素对患感染性疾病的新生儿组织因子途径抑制物影响的观察[J].血栓与止血学,2003,9(4):156-157,181. |
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| 作者姓名： | 李晓静 蔡晓燕 李晓辉 包承鑫 周敏 李晋蜀 李丹 周开宇 |
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| 作者单位： | 成都市儿童医院,成都,610017 |
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| 摘 要： | 目的:观察肝素对患感染性疾病的新生儿组织因子途径抑制物(TFPI)的影响。方法:采用酶联免疫吸附试验(ELISA)法检测了32例患感染性疾病的新生儿在使用肝素前和使用肝素后30～45分钟、6小时血浆TFPI的变化,并与患儿对照组、正常对照组及文献进行比较。结果:患儿治疗组使用肝素后30～45分钟血浆TFPI水平明显增高(t=3.953,P<0.001),6小时血浆TFPI又几乎降至用药前水平(t=0.141,P<0.05)。结论:新生儿对肝素的反应与成人不同。
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| 关 键 词： | 肝素 感染性疾病 新生儿 组织因子途径抑制物 检测 酶联免疫吸附试验 |
| 文章编号： | 1009-6213(2003)04-0156-03 |
Observation of the Effect of Heparin on TFPI in Neonates with Infective Diseases |
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| LI Xiao-jing,CAI Xiao-yan,LI Xiao-hid,ZHOU Ming,BAO Chen-xin,LI Jing-shu,LI Dan,ZHOU Kai-yu. Chengdu Children ' Hospital,Chengdu,..Observation of the Effect of Heparin on TFPI in Neonates with Infective Diseases[J].Chinese Journal of Thrombosis and Hemostasis,2003,9(4):156-157,181. |
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| Authors: | LI Xiao-jing CAI Xiao-yan LI Xiao-hid ZHOU Ming BAO Chen-xin LI Jing-shu LI Dan ZHOU Kai-yu Chengdu Children ' Hospital Chengdu |
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| Affiliation: | LI Xiao-jing,CAI Xiao-yan,LI Xiao-hid,ZHOU Ming,BAO Chen-xin,LI Jing-shu,LI Dan,ZHOU Kai-yu. Chengdu Children ' Hospital,Chengdu,610017. |
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| Abstract: | Objective: To observe the effect of heparin on TEPI in neonates with infective diseases. Methods: Level of plasma TFPI was detected by enzyme linked immunosorbent assay(ELISA)before and 30 - 40 min,6 h after heparin in 32 neonates with infective diseases and compared with the comtrol groups not using heparin, normal neonates and references. Results: Level of plasma TFPI was significantly higher 30 - 45 min after using heparin(t = 3. 593, P < 0.001) than that of control group, but it cpaickly decreased to the level before heparin( t = 0. 141, P < 0. 05) . Conclusion: The reaction of neonates to heparin was different from that of adult. |
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| Keywords: | Neonatal Heparin Tissue factor pathway inhibitor |
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