脂蛋白相关磷酸酶A2和炎性蛋白在诊断脑梗死后血管性痴呆及判断预后中的应用

目的探讨脂蛋白相关磷酸酶A2(Lp⁃PLA2)、炎性蛋白超敏C反应蛋白(hs⁃CRP)、白介素⁃6(IL⁃6)]在脑梗死后血管性痴呆(VD)诊断及预后中的应用价值。方法选取2018年6月至2019年7月本院收治的75例单纯脑梗死患者(无VD组)及60例脑梗死后VD患者(VD组),比较两组临床资料,通过酶联免疫吸附法检测血清Lp⁃PLA2、IL⁃6水平,通过干式免疫层析技术检测血清hs⁃CRP水平,采用Logistic回归性分析影响脑梗死后VD发生的危险因素,采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析各指标诊断脑梗死后VD的价值,采用Pearson分析各指标与美国国立卫生研究院卒中量表(NIHSS)、日常生活活动能力量表评分(ADL)之间的相关性。结果VD组NIHSS、ADL评分及血清Lp⁃PLA2、hs⁃CRP、IL⁃6均较无VD组高(P<0.05);年龄、Lp⁃PLA2、hs⁃CRP、IL⁃6均为影响脑梗死后VD发生的相关危险因素(P<0.05);诊断脑梗死后VD的AUC IL⁃6>hs⁃CRP>Lp⁃PLA2;Lp⁃PLA2、hs⁃CRP和IL⁃6与NIHSS评分呈正相关(P<0.05),与ADL评分呈负相关(P<0.05)。结论Lp⁃PLA2、hs⁃CRP和IL⁃6在脑梗死后VD患者中高表达,且明显与患者预后评分相关,可辅助VD诊断及评估患者功能预后。

Application of lipoprotein-associated phosphatase A2 and inflammatory proteins in diagnosing vascular dementia and predicting prognosis after cerebral infarction

Objective To investigate lipoprotein⁃associated phosphatase A2(Lp⁃PLA2),inflammatory proteinshigh⁃sensitivity C⁃reactive protein(hs⁃CRP),interleukin⁃6(IL⁃6)]and vascular dementia(VD)after cerebral infarction application value in diagnosis and prognosis.Methods From June 2018 to July 2019,75 patients with simple cerebral infarction(without VD group)and 60 patients with VD after cerebral infarction(VD group)were selected,and the clinical data of the two groups were compared.Detection of serum Lp⁃PLA2 and IL⁃6 levels by enzyme⁃linked immunosorbent assay,and detection of serum hs⁃CRP levels by dry immunochromatographic techniques were performed.Logistic regression analysis was used to analyze the risk factors affecting VD after cerebral infarction.And area under the curve(AUC)were used to analyze the value of VD after diagnosis of cerebral infarction.Pearson analysis was used to analyze the correlation between the indicators and the National Institutes of Health Stroke Scale(NIHSS)and the daily activity ability scale score(ADL).Results The NIHSS,ADL scores,and serum Lp⁃PLA2,hs⁃CRP,and IL⁃6 in the VD group were higher than those in the non⁃VD group(P<0.05).Age,Lp⁃PLA2,hs⁃CRP,and IL⁃6 all affected cerebral infarction,related risk factors of post⁃VD(P<0.05).AUC IL⁃6>hs⁃CRP>Lp⁃PLA2 of VD after diagnosis of cerebral infarction.Lp⁃PLA2,hs⁃CRP and IL⁃6 were positively correlated with the NIHSS score(P<0.05),which was negatively correlated with ADL score(P<0.05).Conclusions Lp⁃PLA2,hs⁃CRP and IL⁃6 are highly expressed in patients with VD after cerebral infarction,and are significantly related to the prognosis score of patients,which can assist the diagnosis of VD and evaluate the functional prognosis of patients.