儿童神经母细胞瘤颅面骨转移的CT和MRI表现

目的：探讨神经母细胞瘤颅面骨转移的CT和MRI特征性表现。方法：回顾性分析6例经病理证实的神经母细胞瘤颅面骨转移患者的CT和MRI资料，分析其影像学特征。6例均行头颅CT平扫，其中2例行头颅MRI平扫和增强检查，6例中5例行腹部CT平扫及增强检查，1例行腹部MRI平扫及增强检查。结果：6例均为双侧颅面骨受累，主要CT表现为颅面骨骨质破坏、骨膜下垂直骨针和软组织肿块，软组织肿块中可见钙化；主要MRI表现为颅骨骨质破坏并软组织肿块，其内有钙化灶，肿块于T1WI上呈等信号，T2WI呈稍高信号，增强后可见肿块和邻近脑膜有不均匀轻度强化。5例腹部CT显示腹膜后肿块并钙化，增强后有不均匀强化。1例MRI显示腹膜后肿块。结论：神经母细胞瘤颅骨转移的CT和MRI表现有一定特征性，CT和MRI对本病的诊断有重要价值。

CT and MRI manifestations of metastatic neuroblastoma in craniofacial bones

Objective： To investigate the characteristic findings of metastatic neuroblastoma in craniofacial bones. Methods：CT and MRI features of six children with pathologically confirmed metastatic neuroblastoma in craniofacial bones were evaluated retrospectively. All of the cases underwent plain CT scan of head,2 cases of which underwent plain and contrast-enhanced MRI scan. 5 cases （5/6） underwent upper abdominal plain and contrast-enhanced CT scan and 1 case underwent MRI examination. Results： All the cases had bilateral multiple lesions. The main CT features of metastatic neuroblastoma in craniofacial bone were vermiform destruction, subperiosteal vertical speculated high density areas in involved bones and slightly high density soft tissue mass with calcification. Two cases showed destruction in several craniofacial bones and soft tissue masses with calcification. The masses were showed isointensity on T1-weighted images, mildly high intensity on T2- weighted images. After administration of gadolinium contrast medium,obvious enhancement was assessed in soft tissue masses and meninges. Retroperitoneal masses with calcification and heterogeneous enhancement were assessed on abdominal CT scan of 5 cases, and a retroperitoneal mass was found on MRI. Conclusion..CT and MRI findings of metastatic neuroblastoma in craniofacial bones have some characteristics, and are helpful for the diagnosis before surgery.