体素内不相干运动扩散加权成像对前列腺癌的诊断价值

目的：探讨多b值扩散加权成像（DWI）序列在前列腺癌诊断中的应用价值。方法：经超声引导下行前列腺穿刺活检病理证实为前列腺癌的7例患者及非前列腺癌的4例患者纳入本组研究，所有患者均行多b值DwI序列（b值分别为0、188、375、563和750s／mm2）扫描。应用双指数模型（体素不相干运动模型）进行分析，计算并比较分析前列腺癌区和非癌区的相对纯扩散值D和灌注分数f的差异。结果：癌区的D值和f值分别为（0．77±0．20）×10^-3mm^2／s和（8．66±3．07）％，非癌区的D值和f值分别为（1．53±0．48）×10^-3mm2／s和（2．27±1．16）％。癌区的D值低于非癌区，差异有统计学意义（P〈O．01）；癌区的f值高于非癌区，但差异无统计学意义（P〉0．05）。结论：多b值DWI序列可获取前列腺组织真实水分子扩散运动及微灌注相关信息，可为前列腺癌的诊断提供重要信息。

Preliminary study of intravoxel incoherent motion diffusion-weighted imaging of prostate cancer

Objective：To determine the role of multi b-value DWI in the evaluation of prostate cancer （PCa）. Methods： Seven patients with PCa and four patients without PCa according to the results of biopsy were recruited in the study. All of them underwent the multi b-value DWI （b= 0,188,375,563,750s/mm2 ） examination on a 3.0T MR scanner. Quantitative analysis was conducted by using an intravoxel incoherent motion （IVIM） bbexponential model. Then the pure diffusion co efficient （D） and perfusion fraction （f） in the cancerous and noncancerous areas were calculated and compared （independent t-test） between the two groups. Results：The D and f values in the cancerous areas were （0.77±0.20） × 10 3mm2/s and （8.66± 3.07）%, whereas the D and f values in the noncancerous areas were （1.53 ± 0.48）× 10-3 mm2/s and （2.27±1.16） %. The D values in the cancerous areas were significantly lower than those of the noncancerous areas （P〈0.01）. The f values in the cancerous areas were higher than those of noncancerous areas but there was no statistical difference between the two groups. Conclusion： Multi b-value DWI can reflect the true water diffusion motion and microcirculation perfusion in the prostate. It may be a feasible tool in the diagnosis of prostate cancer.