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Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice |
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| Authors: | Richard W Hyman Susan Frank Craig H Warden Aaron Daluiski Renu Heller Aldons J Lusis |
| Affiliation: | 1. Stanford DNA Sequence and Technology Center, Department of Biochemistry, Stanford University School of Medicine, 94305, Stanford, California 3. Division of Cardiology, Department of Medicine, UCLA, 90024, Los Angeles, California 4. Syntex Research, 3401 Hillview Avenue, 94304, Palo Alto, California 5. Department of Microbiology and Molecular Genetics and Molecular Biology Institute, UCLA, 90024, Los Angeles, California |
| Abstract: | Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumablyApoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus. |
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