| 胆囊收缩素与抑郁症的相关性研究进展 |
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| 引用本文： | 王叶情,王宇红,刘检,赵洪庆,邹蔓姝.胆囊收缩素与抑郁症的相关性研究进展[J].金属学报,2021,26(6):672-679. |
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| 作者姓名： | 王叶情 王宇红 刘检 赵洪庆 邹蔓姝 |
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| 作者单位： | 1.湖南中医药大学科技创新中心，长沙 410208，湖南；;2.湖南中医药大学第一附属医院，长沙 410007，湖南 |
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| 基金项目： | 国家“重大新药创制”科技重大专项（No.2017ZX09309026）；湖南省自然科学基金项目（No.2019JJ50428）；湖南省教育厅一般项目（No.19C1437）；湖南省科技厅重点项目（No.2018DK2014）；湖南省研究生创新项目（No.CX20200763） |
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| 摘 要： | 抑郁症是以显著而持久的情绪低落为主要特征的精神性疾病。新近研究发现，胆囊收缩素（cholecystokinin, CCK）作为一种脑肠肽（brain gut peptide, BGP）小分子，其广泛分布于中枢神经系统（central nervous system, CNS）和肠神经系统（enteric nervous system, ENS），为进一步明确CCK与抑郁症发病机制的联系，本文就CCK在抑郁症中的作用及作用机制包括下丘脑-垂体-肾上腺轴（hypothalamic-pituitary-adrenal axis, HPA）、突触功能、分子及环路机制等方面作一综述。
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| 关 键 词： | 抑郁症 胆囊收缩素 神经元 机制 |
| 收稿时间： | 2020-11-02 |
| 修稿时间： | 2021-05-17 |
Research progress of relevance between cholecystokinin and depression |
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| WANG Yeqing,WANG Yuhong,LIU Jian,ZHAO Hongqing,ZOU Manshu.Research progress of relevance between cholecystokinin and depression[J].Acta Metallurgica Sinica,2021,26(6):672-679. |
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| Authors: | WANG Yeqing WANG Yuhong LIU Jian ZHAO Hongqing ZOU Manshu |
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| Affiliation: | 1. Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China;2.The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan, China |
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| Abstract: | Depression is a mental illness characterized by significant and lasting depression. Recent studies have found that cholecystokinin, as a small brain-gut peptide molecule, is widely distributed in the central nervous system and enteric nervous system. In order to further clarify the relationship between CCK and the pathogenesis of depression, this article reviews the effect of CCK in depression, including HPA axis, synaptic function and circuit mechanism, etc. |
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