发作性睡病临床表现与治疗研究进展

发作性睡病（narcolepsy）是一种罕见的睡眠-觉醒障碍性疾病，分为1型（NT1）和2型（NT2）。NT1所占比例超过3/4，其临床特点包括日间过度思睡（EDS）、猝倒发作及夜间睡眠症状（如睡眠瘫痪、睡眠幻觉、睡眠中断、睡眠运动障碍等），并伴随代谢功能障碍、精神和情感障碍等。NT2临床表现主要为EDS，没有猝倒发作，而其他NT1型出现的症状在NT2患者中亦不明显。发作性睡病的治疗主要包括治疗EDS、抗猝倒发作、改善夜间睡眠等。本文将从研究进展的角度阐述发作性睡病的临床表现与治疗前沿。

Progresses in clinical manifestations and treatments of narcolepsy

Narcolepsy is a rare disease that presents with sleep-wake disorder, which divided into narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). NT1 accounts for more than 75%, which is characterized by excessive daytime sleepiness (EDS), cataplexy attacks and nocturnal sleep symptoms (e.g. sleep paralysis, hallucinations, sleep disruptions, sleep movement disorders, etc.), accompanied by metabolic, psychiatric and emotional disturbances. The main clinical manifestation of NT2 is EDS, without cataplexy and nonspecific other symptoms of NT1. The treatments of narcolepsy mainly include the treatments of EDS and cataplexy, as well as the improvement of nocturnal sleep. This article will elaborate the advances in clinical manifestations and treatments of narcolepsy.