血清学IgM检测在儿童呼吸道感染中的临床意义

目的对呼吸道感染患儿的几种常见病原体进行血清学检测,从而评价血清学IgM检测的临床意义。方法选取360例呼吸道感染的患儿作为调查对象,用酶联免疫吸附测定（ELISA）法对血清IgM进行检测,测定患儿血清中CMV-IgM、HSV-IgM、EBV-IgM、RSV-IgM、MPM-IgM的情况,分析抗体阳性率、不同性别和不同年龄组抗体阳性率的差异。结果本次研究检测出IgM抗体阳性率为76.7%,其中,CMV-IgM阳性率为17.2%,HSV-IgM阳性率为9.7%,EBM-IgM阳性率为9.2%,RSV-IgM阳性率为20.8%,MPM-IgM阳性率为19.7%,各类抗体的阳性率比较差异有高度统计学意义（χ2=35.98,P〈0.01）。男性患儿阳性率为72.4%,女性患儿阳性率为82.7%,男性患儿与女性患儿的阳性率差异无统计学意义（χ2=0.58,P〉0.05）。〈1岁组检测各类抗体合计IgM阳性率为85.3%,1-〈4岁组为85.3%,4-6岁组为62.3%,〉6岁组为78.0%,不同年龄组间抗体的阳性率差异具有高度统计学意义（χ2=19.14,P〈0.01）。CMV-IgM、HSV-IgM及EBM-IgM的阳性率在不同年龄组间差异无统计学意义;RSV-IgM的阳性率在各年龄组间有差异（χ2=11.37,P〈0.01）,1-〈4岁组的阳性率（37.04%）高于其他年龄组;MPM-IgM的阳性率在各年龄组间也有差异（χ2=28.48,P〈0.01）,〉6岁组的阳性率（49.30%）高于其他年龄组。结论血清学IgM检测能够作为儿童呼吸道感染患儿的早期指标,在临床合理用药、降低患者不必要经济损失方面具有重要的临床意义。

Clinical significant of serological IgM test on the respiratory tract infection among children

Objective To conduct serological test on the respiratory tract infection among children,so as to evaluate the clinical effect of serological IgM test.Methods A total of 360 children were collected in our study.ELISA method was taken to perform the IgM test,and the CMV-IgM,HSV-IgM,EBV-IgM,RSV-IgM and MPM-IgM were also test ed.The positive rate of antibody of different genders and ages were analyzed.Results The positive rate of antibody IgM was 76.7%,of which the positive rate of antibody CMV-IgM was 17.2%,the positive rate of antibody HSV-IgM was 9.7%,the positive rate of antibody EBM-IgM was 9.2%,the positive rate of antibody RSV-IgM was 20.8%,and the positive rate of antibody MPM-IgM was 19.7%.There was significant difference among these positive rates（χ2= 35.98,P 0.01）.The positive rate of males was 72.4%,and was 82.7% among females.There was no significant dif ference between positive rates between males and females（χ2=0.58,P 0.05）.The positive rates of IgM of 0-1 years old age group,1-4 years old age group,4-6 years old age group and above 6 years old age group were 85.3%,85.3%,62.3% and 78.0% respectively.There was significant difference of positive rates among different age groups（χ2=19.14,P0.01）.There was no significant difference among positive rates of CMV-IgM,HSV-IgM and EBM-IgM.There was significant difference in the positive rates of different age groups（χ2=11.37,P 0.01）.The positive rate of 1-4 years old group（37.04%） was significant higher than other age groups.The positive rate of MPM-IgM showed significant difference in different age groups（χ2=28.48,P 0.01）.The positive rate of 6 years old group（49.30%） was significant higher than other age groups.Conclusion The serological IgM test could be an early indexes for respiratory tract infection among children,we could decrease the economic lose in clinics.