阿托伐他汀对不稳定型心绞痛患者PCI术后心肌损伤及炎症反应的影响

目的探讨阿托伐他汀常规剂量治疗对不稳定型心绞痛（UAP）患者经皮冠状动脉介入术（PCI）后,心肌损伤的标记物血清肌酸磷酸激酶同功酶（CK-MB）、血浆肌钙蛋白Ⅰ（cTnI）及炎症反应标志物超敏C反应蛋白（hs-CRP）的变化。方法根据UAP患者PCI术前4周是否持续服用阿托伐他汀20mg/d分为试药组和对照组,于术前和术后8h、24h抽取肘静脉血检测血浆CK-MB、cTnI和hs-CRP。结果PCI术后两组心肌损伤及炎症反应的标记物均有不同程度升高,但试药组CK-MB、cTnI、hs-CRP水平显著低于对照组（均P<0.01）。结论UAP患者在PCI术前4周持续口服阿托伐他汀20mg/d能明显减少PCI术对UAP患者造成的心肌损伤及炎症反应。

Effect of atorvastatin on myocardial injure and inflammatory reaction from PCI in patients with unstable angina pectoris

AIM To study the effect of atorvastatin on myocardial injure and inflammatory reaction from percutaneous coronary intervention(PCI)in patients with unstable angina pectoris. The markers of myocardial injure are CK-MB and cardiac troponin (cTnI). The marker of inflammatory reaction is high-sensitivity C-reactive protein (hs-CRP). METHODS The two treatment groups received atorvastatin 20 mg daily or non-atorvastatin 4 successive weeks before PCI,CK-MB,cTnI and hs-CRP of the blood from elbow vein were monitore...