大黄酚对小鼠记忆障碍的作用及其机制分析

目的　研究大黄酚对AlCl3致急性衰老模型小鼠记忆障碍的保护作用及其机制分析。方法　以AlCl3(60mg·kg- 1 sc,7d)造成小鼠记忆障碍模型 ,采用小鼠避暗试验和跳台试验 ,观察大黄酚 (1 0、1、0 1mg·kg- 1 ip ,1 5d)对记忆障碍模型小鼠的保护作用 ,并于d 1 6对各剂量组小鼠进行脑组织超氧化物歧化酶 (SOD)活性及血浆和脑组织谷胱甘肽过氧化物酶 (GSH px)活性测定。 结果　大黄酚各个剂量组均能明显改善AlCl3所致被动回避性记忆障碍 ,增加SOD和GSH px活性。 结论　大黄酚对AlCl3致急性衰老小鼠记忆障碍有保护作用 ,其作用机制可能是通过增强抗氧化酶GSH px和SOD活性 ,清除氧自由基对中枢神经系统神经细胞的损伤

Effects of chrysophanol on memory impairment mice and its mechanism analysis

AIM To study the protective effects and mechanism of chrysophanol on learning and memory impairment of mice with acute senile model induced by AlCl 3. METHODS After sc of AlCl 3 60 mg·kg -1 for 7 d and ip chrysophanol 10,1,0 1 mg·kg -1 for 15 d, using step-through test and step-down test, the effect of chrysophanol on learning and memory was observed and the superoxide dismutase (SOD) activities in cerebrum and glutathione peroxidase (GSH-px)activities in plasma and cerebrum were measured. RESULTS Chrysophanol 10,1,0 1 mg·kg -1 significantly improved me mory impairment induced by AlCl 3 and enhanced the activities of GSH- px and SOD. CONCLUSION Chrysophanol showed protective effect on br ain memory impairment of mice in acute senile model induced by AlCl 3, perhaps the mechanism is involved in enhancing the activities of GSH-px and SOD, cleari ng away the oxygen radicals, protecting the brain neurons from the harm of lipop eroxide.