| Construction of retroviral vectors to induce a strong expression of human interferon-β gene in human hepatoma cells |
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| 引用本文： | 曹广文,高军,杨文国,戚中田,杜平,孔宪涛.Construction of retroviral vectors to induce a strong expression of human interferon-β gene in human hepatoma cells[J].中国人民解放军军医大学学报,1997(1). |
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| 作者姓名： | 曹广文 高军 杨文国 戚中田 杜平 孔宪涛 |
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| 作者单位： | Department of Microbiology，Second Military Medical University，Shanghai，200433 |
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| 摘 要： | ClassIinterferonisapotent1mmunemodu-latingfactorinvivo,andplaysanimportantrolelnactivatinganti-tumorcytotoxicTlymphocytesandnonuspecificeffectorcellssuchasNKcellsLlJ.ln-terferonandmanyothercytokinegeneswereintro-ducedintotumorcells,tumorinterstitialcellsandtumorinfiltratinglymphocytes'-']inordertosustainaneffectiveanti-tumorconcentrationofcy-tokinelocatedattumorsites.Itwasshownthatsomecytokinegenemodifiedtumorcellslosttheirtumorigenicityandinhibitedthegrowthofparentaltumorinanimalmodels.Pra…
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