幽门螺杆菌根除效果与中医证型相关性研究

目的探讨幽门螺杆菌（Hp）根除效果与中医证型的相关性，为提高中医临床Hp根除率提供依据。方法对922例Hp感染阳性患者进行中医辨证分型，统一经过四联疗法治疗后，分析不同中医证型Hp感染者的根除效果。结果在922例Hp感染者中，不同中医证型者Hp根除效果依次为脾胃虚寒证〈寒热夹杂证〈胃阴亏虚证〈胃络瘀血证〈肝气犯胃证〈肝胃郁热证〈脾胃湿热证，差异有统计学意义（P〈0．05）。实证（包括脾胃湿热证、肝胃郁热证、肝气犯胃证及胃络瘀血证）者623例，根除率为82．5％；虚证（脾胃虚寒证、胃阴亏虚证）者244例，根除率为58．6％。二者比较，差异有统计学意义（P〈0．05）。实证各证型间Hp根除率差异有统计学意义（P〈0．05），虚证两证型间Hp根除率差异无统计学意义（P〉0．05）。结论不同证型Hp感染者根除效果不同，虚证明显低于实证。

Relationship between Hp Eradication Effect and TCM Syndrome Types

Objective To discuss the relationship between Hp eradication effect and TCM syndrome types, and provide basis for improving clinical Hp eradication rate of TCM. Methods TCM syndrome types of 922 Hp-positive patients were distinguished. After treatment by the quadruple chemotherapy, the effect of Hp eradication of different TCM syndrome type was analyzed. Results In 922 Hp infectors, Hp eradication effect in different TCM syndrome type from low to high was as follows： spleen-stomach deficiency-coldness, cold-heat complication, stomach-yin deficiency, congestion of stomach coUaterals, hyperactive liver-qi harmful to stomach, liver-stomach heat, spleen-stomach dampness-heat, with significant difference （P〈 0.05）. A total of 623 patients were discriminated as excessive syndrome （including spleen-stomach dampness-heat, liver-stomach heat, hyperactive liver-qi harmful to stomach and congestion of stomach collaterals）, and its eradication rate was 82.5%. A total of 244 patients were discriminated as deficient syndrome （including spleen-stomach deficiency-coldness and stomach-yin deficiency）, and its eradication rate was 58.6%. The difference between excessive syndrome and deficient syndrome was statistically significant （P〈0.05）. Hp eradication effect among different TCM syndrome types of excessive syndrome had statistical difference （P 〈0.05）, while that of deficient syndrome had no statistical difference （P 〉0.05）. Conclusion The eradication rate of Hp infection was different in patients with different TCM syndrome types, which in deficient syndrome is obviously lower than in excessive syndrome.