上海市松江区成人血尿酸水平与肾脏损害的关系

 【摘要】目的 探讨上海市松江区成人血尿酸水平与肾脏损害的相关性。方法 对2006至2011年上海市松江区34 212例体检者进行大样本量的临床调查,根据性别、尿检结果、肾功能及血尿酸水平分组,分析血尿酸水平的流行病学特征，比较蛋白尿、血尿和内生肌酐清除率的变化。结果 总体高尿酸血症患病率为18.67%(男性26.82%,女性9.99%),男性平均血尿酸值为(377.64±79.23) μmol/L,显著高于女性(273.87±66.02) μmol/L (P<0.01)。血尿酸平均值与年龄呈正相关(r=0.22,P<0.01)。女性血尿比例高于男性,蛋白尿阳性率低于男性(P<0.01),血尿酸与血肌酐呈正相关,而与内生肌酐清除率呈负相关(P<0.01)。随着血尿酸水平的升高,血尿阳性率变化不明显,尤其是男性组(P=0.65),但尿蛋白阳性率呈显著升高趋势(P<0.01)。Logistic回归分析提示高尿酸血症是蛋白尿和慢性肾功能不全的独立危险因素。结论 血尿酸水平与蛋白尿的发生有关,血尿酸水平增高可加重肾脏损害。

Correlations between the level of serum uric acid and renal injury in the adults of Songjiang District in Shanghai,China

【Abstract】Objective To investigate the correlations between the level of serum uric acid and renal injury in adults. Methods Data from 34 212 medical subjects in Songjiang District of Shanghai were collected during 2006 to 2011,and they were divided into different groups based on the gender,urine detection results,renal function and levels of serum uric acid.Epidemiological characteristics of serum uric acid was analyzed.Proteinuria,hematuria and creatinine clearance were compared between different groups. Results The overall morbidity of hyperuricemia was 18.67% (male 26.82% and female 9.99%).The mean level of serum uric acid in male group was (377.64±79.23) μmol/L,higher than that in female group of (273.87±66.02) μmol/L (P<0.01).There was a positive correlation between ages and the mean level of serum uric acid both in male and in female groups (r=0.22,P<0.01).Hematuria was more common in female group,while proteinuria was more common in male group (P<0.01).The level of serum uric acid was positively related with the level of serum creatinine,and negatively related with the level of creatinine clearance (P<0.01).With the increasing level of serum uric acid,there was no significant difference in morbidity of hematuria,especially in male group (P=0.65),while there was significant increasing trend in morbidity of proteinuria (P<0.01).After logistic regression analysis,hyperuricemia was thought as an independent risk factor for proteinuria and chronic renal dysfunction.
Conclusions The level of serum uric acid is related to the occurrence of proteinuria in medical patients.The increasing level of serum uric acid can aggravate kidney injury.