| 酸性离子液体催化aldol反应研究 |
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| 引用本文： | 秦永华,史海波,田宗明.酸性离子液体催化aldol反应研究[J].精细化工中间体,2014(6):52-54. |
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| 作者姓名： | 秦永华 史海波 田宗明 |
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| 作者单位： | 浙江医药高等专科学校 |
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| 基金项目： | 浙江省教育厅科研项目(Y200909511),浙江省教育厅科研项目(Y201122555);宁波市自然科学基金项目(2014A610210);浙江医药高等专科学校校级课题(ZPCSR2011006)资助 |
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| 摘 要： | 以甲酰胺和氯丙酮等为原料合成了离子液体4-甲基-3-丁基噻唑硫酸氢盐。以aldol反应为探针,探究了离子液体催化苯甲醛与丙酮的缩合反应,并对催化剂用量、醛酮比、反应时间和催化剂重复利用等进行了考察。优化工艺条件为:n(苯甲醛)∶n(丙酮)=1.0∶1.8,催化剂用量3%(n/n),反应时间1.5 h,苄叉丙酮的收率达81.2%,催化剂重复使用5次仍可保持较高催化效果。
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| 关 键 词： | 离子液体 aldol反应 噻唑 苄叉丙酮 |
Study on the Aldol Reaction of Benzaldehyde and Acetone Catalyzed by 4-Methyl-3-butylthiazole Bisulfate |
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| QIN Yong-hua;SHI Hai-bo;TIAN Zong-ming.Study on the Aldol Reaction of Benzaldehyde and Acetone Catalyzed by 4-Methyl-3-butylthiazole Bisulfate[J].Fine Chemical Intermediates,2014(6):52-54. |
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| Authors: | QIN Yong-hua;SHI Hai-bo;TIAN Zong-ming |
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| Affiliation: | QIN Yong-hua;SHI Hai-bo;TIAN Zong-ming;Zhejiang Pharmaceutical College; |
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| Abstract: | 4-Methyl-3-butylthiazole bisulfate was synthesized from formamide. This acidic ionic liquid was used as the catalyst for aldol reaction. The amount of catalyst, the aldehyde/ketone ratio, the reaction time and the reproducibility of catalytic ability were studied on the condensation reaction between benzaldehyde and acetone. Best result with 81.2% yield was obtained under the conditions of aldehydes/ketones ratio of 1.0：1.8, the amount of catalyst of 3% and the reaction time of 1.5 hrs. The catalyst can be reused for 5 times. |
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| Keywords: | ionic liquid aldol reaction thiazole benzylideneacetone |
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