West综合征患儿多药耐药基因P糖蛋白的表达水平

目的:探讨West综合征与多药耐药基因（MDR）的关系。 方法:采用流式细胞术检测West综合征（n=12）、部分性发作癫痫(n=9)、全身性发作癫痫患儿(n=8)及正常健康儿童(n=8)外周血淋巴细胞膜MDR P糖蛋白（P170）的表达水平。 结果:普通癫痫(上述部分性发作及全身性发作)患儿和West综合征患儿外周血P170表达水平均增高，其中West综合征患儿外周血P170表达水平(59.52%)明显高于正常对照组（1.22%）及普通癫痫组(11.47%)(P<0.001,P<0.05)。 结论:MDR P170表达增高可能为West综合征难治的重要原因。

Expression of multidrug resistance gene in patients with West syndrome

Objective To study the relationship between West syndrome and multidrug resistance gene (MDR). Methods The expressive levels of perihemo-lymphcyte membrance glycoprotein (P170) in patients with West syndrome(n=12),partial seizures (n=9),generalized seizures (n=8), and 8 healthy children were detected by flow cytometry. Results The expressive levels of perihemo- glycoprotein 170(P170) increased in patients with common epilepsy and West syndrome, compared with the healthy group;the expressive level of P170 in patients with West syndrome (59.52%) was strongly higher than that in the control group (1.22%)(P<0.001) and common epilepsy group (11.47%)(P<0.05).Conclusion The increasing of the expressive level of multidrug resistance gene P170 may be the important cause of difficulty in therapy of West syndrome.