| 肝脏耐受性树突状细胞与肝移植免疫研究进展 |
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| 引用本文： | 吴龙龙,宋红丽.肝脏耐受性树突状细胞与肝移植免疫研究进展[J].中华肝胆外科杂志,2021(2). |
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| 作者姓名： | 吴龙龙 宋红丽 |
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| 作者单位： | 南开大学医学院;天津市第一中心医院器官移植科 |
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| 基金项目： | 国家自然科学基金(81670574、81441022、81270528)。 |
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| 摘 要： | 树突状细胞是调节机体免疫的关键细胞,其中具有免疫抑制功能的耐受性树突状细胞(Tol-DC)在诱导和维持免疫耐受中发挥着重要作用。近年来发现的具有呈递抗原水平低下、抑制T细胞活化与增殖的一类肝脏Tol-DC成为减轻肝移植排斥反应的研究热点。目前已有多种策略用以诱导表型稳定的Tol-DC,为其临床应用奠定了基础。本文总结了肝脏Tol-DC和其调控肝移植免疫机制方面的研究进展。
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| 关 键 词： | 肝移植 免疫耐受 移植免疫学 树突状细胞 |
Liver tolerogenic dendritic cells and liver transplantation immunity |
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| Wu Longlong,Song Hongli.Liver tolerogenic dendritic cells and liver transplantation immunity[J].Chinese Journal of Hepatobiliary Surgery,2021(2). |
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| Authors: | Wu Longlong Song Hongli |
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| Affiliation: | (School of Medicine,Nankai University,Tianjin 300192,China;Department of Organ Transplantation,Tianjin First Central Hospital,Tianjin Key Laboratory of Organ Transplantation,Tianjin Clinical Research Center for Organ Transplantation,School of Medicine,Tianjin 300192,China) |
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| Abstract: | Dendritic cells are the key cells to regulate immunity.Tolerogenic dendritic cells(Tol-DC)with immunosuppressive function play an important role in inducing and maintaining immune tolerance.In recent years,a class of liver Tol-DC with low level of presenting antigen and inhibition of T cell activation and proliferation has become a research hotspot to reduce the rejection of liver transplantation.At the same time,there are many strategies to induce phenotypic stable Tol-DC,which lays a foundation for its clinical application.This article introduces the current understanding of liver Tol-DC and its mechanism of regulating the immunity of liver transplantation,in order to provide new ideas for immunotherapy of liver transplantation. |
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| Keywords: | Liver transplantation Immune tolerance Transplantation immunology Dendritic cells |
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