| FI,FIS等载体衍生物对兔血小板聚集和TXB2释放的影响 |
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| 引用本文： | 杨俊旺,李天锡.FI,FIS等载体衍生物对兔血小板聚集和TXB2释放的影响[J].兰州医学院学报,1999,25(1):10-12. |
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| 作者姓名： | 杨俊旺 李天锡 |
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| 作者单位： | [1]解放军兰州医学院专科学校 [2]兰州医学院 |
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| 摘 要： | 目的 通过测定兔血小板聚集和ＴＸＢ２的含量，比较观察Ｆ、Ｉ、ＦＩ、ＦＩＳ在抗血栓方面的药理作用特点。方法 用比浊法＾（４）和放免法＾（７）测定Ｆ、Ｉ、ＦＩ、ＦＩＳ在体外对兔血小板聚集及释放的ＴＸＢ２的影响。结果 连有阿魏到和吲哚美辛的载体衍生物ＦＩ，ＦＩＳ可抑制ＡＡ、ＡＤＰ诱导的血小板聚集，在１０￣２５０μｍｏｌ·Ｌ＾－１的剂量范围内，两药的作用呈剂量依赖关系，ＦＩ、ＦＩＳ２４０μｍｏｌ·＾－１对
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| 关 键 词： | 阿魏酸 吲哚美辛 血小板聚集 血栓素B2 |
Influences of FI,FIS on rabbit platelet aggregation and TXB2 production. |
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| YANG Junwang,LI
Tianxi,LI Wenguang,et al..Influences of FI,FIS on rabbit platelet aggregation and TXB2 production.[J].Journal of Lanzhou Medical College,1999,25(1):10-12. |
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| Authors: | YANG Junwang LI
Tianxi LI Wenguang |
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| Affiliation: | YANG Junwang,LI
Tianxi,LI Wenguang,et al.Department of Pharmacology.Lanzhou Military Medical
College,PLA,Lanzhou 730020 |
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| Abstract: | Objective To investigate the effect of
IndomethacinumFerulate acid(FI) and IndomethacinumFerulate acidstarch (FIS) on rabbit platelet
aggregation induced by ADP and AA and thromboxane B2production. Methods Influences of
F,I,FI,FIS on rabbit platelet aggregation and TXB2 production were assaied by born GVR and
RIA. Results Both FI and FIS 12.5,60.0,240.0 molL-1,could inhibit the rabbits platelets
aggregation induced by adenosin diphosphate (ADP,2.0molL-1),arachidonic acid (AA,33.3
molL-1).Which showed a good doseeffect relationship.The inhibitions by 10300 molL-1 were
dependent FI 25.059.32%,FIS 13.1239.09%(ADPinduced),FI 29.96%63.06%),FIS
11.47%39.56%(AAinduced).inhibit the ptoduction of TXB2 as well,(AAinduced)FI 40.60%,FIS
28.74%(240.0 molL-1)for TXB2. Conclusions There are positive correlations between the
inhibition of platelet aggregation and TXB2 and effect mechanism on speranskia tuberculata. |
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| Keywords: | Ferulic acidIndomethacin FerulicIndomethacin-target moleculeAdenosine diphosphateArachidonic acidPlatelet aggregationTXB2 |
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