达菲林在体外受精-胚胎移植中的应用

目的:观察达菲林在体外受精-胚胎移植中的疗效。方法:根据112例不孕患者用药前窦卵泡的数目采用不同剂量的达菲林降调节,常规超促排卵至卵泡成熟后,经阴道B超引导下取卵,行实验室体外培养受精,优质胚胎移植。结果:3组获卵数、获得的Ⅰ级胚胎数、胚胎移植后临床妊娠率、卵巢过度刺激综合征发生率等均无明显差异,受精率皆在70％以上,卵裂率在93％以上。结论:不同剂量的达菲林降调节均可获得高质量的卵子,且是一种肌肉注射缓释剂,易被患者接受。

The Use of Diphereline in vitro Fertilization and Embry-o Transfer (IVF-ET)

Objective: To check the effect of Diphereline in IVF - ET. Methods; Using several doses of Diphereline on 112 infertile patients according to the number of their basic oocytes respectively, using conventional tropic superovulation until the maturing of the oocytes. Oocytes were extracted by transvaginal ultrasound guided. In vitro fertilization, cleavage were carried in cultural laboratory. Embryo of high - quality were chosen and transferred into the uterus. Results: There is no obvious difference on the number of oocytes obtained and grade I oocytes obtained, the rate of clinical pregnancy, the occurrence rate of ovarian gyperstimulation syndrome. The fertilization rates were above 70%. The cleavage rate were above 93%. Conclusion : Different doses of Diphereline are very helpful to obtain high - quality oocytes and prone to be accepted by the patients as a delay - released medicine.