血府逐瘀汤治疗原发性肝癌TACE术后气滞血瘀型疼痛30例

目的 观察血府逐瘀汤治疗原发性肝癌经导管动脉化疗栓塞（transcatheter arteriachemoembolization, TACE）术后气滞血瘀型疼痛的临床疗效。 方法 将60例原发性肝癌TACE术后气滞血瘀型疼痛患者随机分为治疗组和对照组，每组30例。治疗组给予血府逐瘀汤口服，对照组予以中药汤剂安慰剂口服。治疗前后比较两组患者疼痛数字分级评分（numerical rating scale, NRS）及Karnofsky功能状态评分（karnofsky performance status, KPS）的变化。 结果 治疗后两组NRS评分均显著下降，治疗组治疗前后NRS评分差值显著大于对照组（P＜0.05）。治疗后对照组KPS评分显著降低，而治疗组显著升高，两组治疗前后差值比较，差异具有统计学意义（P＜0.05）。治疗组NRS及KPS评分改善情况均显著优于对照组（P＜0.05）。 结论 血府逐瘀汤能有效减轻原发性肝癌TACE术后气滞血瘀型疼痛，提高患者生活质量。

Clinical Efficacy of Xuefu Zhuyu Decoction in Treatment of Pain with Qi Stagnation and Blood Stasis after Transcatheter Arterial Chemoembolization for Primary Liver Cancer: An Analysis of 30 Cases

Objective To investigate the clinical efficacy of Xuefu Zhuyu Decoction in the treatment of pain with qi stagnation and blood stasis after transcatheter arterial chemoembolization (TACE) for primary liver cancer. Methods A total of 60 patients who experienced pain with qi stagnation and blood stasis after TACE for primary liver cancer were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the treatment group were given oral Xuefu Zhuyu Decoction, and those in the control group were given oral traditional Chinese medicine decoction as placebo. The numerical rating scale (NRS) score for pain and Karnofsky performance status (KPS) score were compared before and after treatment and between the two groups. Results The two groups showed significant reductions in NRS score after treatment (P<0.05), and the treatment group had a significantly greater reduction in NRS score compared with the control group (P<0.05). After treatment, the KPS score showed a significant decrease in the control group and a significant increase in the treatment group (P<0.05). Compared with the control group, the treatment group had significantly better improvements in NRS and KPS scores (P<0.05). Conclusion Xuefu Zhuyu Decoction can effectively relieve the pain with qi stagnation and blood stasis after TACE for primary liver cancer and improve patients'' quality of life.