多囊卵巢综合征体质指数、性激素及胰岛素抵抗水平与中医证型相关性研究

目的 探讨多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者的体质指数、性激素和胰岛素水平与中医证型的相关性。方法 选择91例PCOS患者（肝经湿热型50例、痰湿阻滞型41例），观察并比较两种证型患者的人体测量学指标、性激素及空腹血糖(fasting plasma glucose，FPG)、空腹胰岛素(fasting insulin，FINS)、稳态模型胰岛素抵抗指数(homeostasis model assessment of insulin resistance，HOMA-IR)水平。结果 痰湿阻滞型患者的体质指数(body mass index，BMI)、腰臀比（waist-to-hip ratio，WHpR）、腰身比（waist-height ratio，WHtR）均明显高于肝经湿热型患者（P<0.05）；痰湿阻滞型患者FPG、FINS、HOMA-IR水平均明显高于肝经湿热型患者（P<0.05）；肝经湿热型患者黄体生成激素(luteinizing hormone，LH)、卵泡刺激素(follicle stimulating hormone，FSH)水平明显高于痰湿阻滞型患者（P<0.05）。结论 PCOS痰湿阻滞型患者BMI、WHpR、WHtP等人体测量学指标和FPG、FINS、HOMA-IR水平明显高于肝经湿热型患者，LH、FSH水平明显低于肝经湿热型患者。

Association of Body Mass Index, Sex Hormone, and Insulin Resistance with Traditional Chinese Medicine Syndrome Types in Patients with Polycystic Ovary Syndrome

Objective To investigate the association of body mass index, sex hormone, and insulin resistance with traditional Chinese medicine (TCM) syndrome types in patients with polycystic ovary syndrome (PCOS). Methods A total of 91 patients with PCOS (50 patients with liver channel damp-heat syndrome and 41 patients with phlegm-dampness stagnation syndrome) were enrolled. The anthropometric indices, sex hormone, fasting plasma glucose (FPG), fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) were observed and compared between these two groups. Results Compared with the liver channel damp-heat syndrome group, the phlegm-dampness stagnation syndrome group had significantly higher body mass index (BMI), waist-to-hip ratio (WHpR), waist-height ratio (WHtR), FPG, FINS, and HOMA-IR (P<0.05). Compared with the phlegm-dampness stagnation syndrome group, the liver channel damp-heat syndrome group had significantly higher levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) (P<0.05). Conclusion Compared with those with liver channel damp-heat syndrome, the PCOS patients with phlegm-dampness stagnation syndrome have significantly higher anthropometric indices such as BMI, WHpR, and WHtR, FPG, FINS, and HOMA-IR and significantly lower levels of LH and FSH.