结直肠癌免疫检查点治疗的研究进展

目前免疫治疗正在非小细胞肺癌、黑色素瘤、膀胱癌等各个瘤种中如火如荼地开展，其治疗方法也多种多样，包括肿瘤疫苗治疗、过继性T细胞疗法、免疫检查点抑制剂治疗等，但目前结直肠癌免疫治疗主要集中于免疫检查点抑制剂（PD-1/PD-L1及CTLA-4抑制剂等）。自从PD-1/PD-L1抑制剂在dMMR/MSI-H晚期结直肠癌患者上表现出较好的疗效以来，免疫检查点抑制剂在结直肠癌领域获得了越来越多的关注，治疗方案也从晚期后线治疗逐渐移至一线治疗或新辅助治疗并获得了成功，本文就近年来国内外结直肠癌免疫检查点治疗的研究进展作一综述。

Research Progress of Immune Checkpoint Therapy on Colorectal Cancer

At present,immunotherapy is in full swing in the treatment of non-small cell lung cancer,melanoma,bladder cancer and other tumor species,and its treatment methods are also diverse,including tumor vaccine treatment,adoptive T cell therapy,immune checkpoint inhibitor treatment,etc,but current immunotherapy for colorectal cancer mainly focuses on immune checkpoint inhibitors(PD-1/PD-L1 and CTLA-4 inhibitors).Since PD-1/PD-L1 inhibitors have shown amazing efficacy in patients with dMMR/MSI-H advanced colorectal cancer,immune checkpoint inhibitors have gained more and more attention in the field of colorectal cancer,and the treatment options have gradually shifted from late line treatment to first-line treatment or neoadjuvant therapy,and have achieved success.This paper summarizes the research progress of immune checkpoint therapy on colorectal cancer.