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Analysis of Age-Related Global DNA Methylation in Chicken |
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| Authors: | Magdalena Gryzinska Ewa Blaszczak Aneta Strachecka Grazyna Jezewska-Witkowska |
| Affiliation: | 1. Department of Biological Basis of Animal Production, Faculty of Biology and Animal Breeding, University of Life Sciences in Lubin, Lublin, Poland 2. CNRS, UMR 6290, Institut de Génétique et Développement de Rennes, 5043, Rennes, France 3. Faculté de Médecine, Université de Rennes 1, UEB, IFR 140, 5043, Rennes, France |
| Abstract: | DNA methylation is an epigenetic modification that plays an important role in the normal development and function of organisms. The level of DNA methylation is species-, tissue-, and organelle-specific, and the methylation pattern is determined during embryogenesis. DNA methylation has also been correlated with age. The aim of this study was to determine the global DNA methylation levels and their correlation with age in the chicken, using a Polish autosexing chicken breed, Polbar. A quantitative technique based on an immunoenzymatic assay was used for global DNA methylation analysis. The results show increased global DNA methylation levels with older Polbar embryos. Global DNA methylation levels decrease with the age of hens in the postembryonic stage. This study expands the current knowledge of the Polbar epigenome and the general knowledge of the function of epigenetic mechanisms in birds. |
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