母婴间乙型肝炎与丙型肝炎双重感染的研究

从流行病角度，利用分子生物学技术及免疫学方法，对２１０例产妇血清及新生儿 脐带血清，应用聚合酶链反应（ＰＣＲ）、反转录聚合酶链反应（ＲＴ－ＰＣＲ），检测乙型肝炎病毒（ＨＢＶ） 及丙型肝炎病毒（ＨＣＶ）标志物，其结果为：ＨＢｓＡｇ阳性产妇的新生儿阳性率为６５．５％，ＨＢｅＡｇ阳 性产妇的新生儿阳性率为８１．８％，抗－ＨＣＶ阳性产妇的新生儿阳性率为７５．０％，ＨＢＶ－ＤＮＡ及 ＨＣＶ－ＲＮＡ双重阳性产妇的新生儿阳性率为１００．０％，说明母婴间存在乙型肝炎（ＨＢ）、丙型肝炎 （ＨＣ）及双重感染，其垂直传播可发生于宫内及围产期，是婴幼儿患病毒性肝炎的主要感染途径。 由于乙型肝炎及丙型肝炎的临床表现无特异性，不能从临床症状和体征中得以诊断，所以建立敏 感、特异的实验检测方法，为临床提供早期诊断依据，建立围产期保健制度，分娩过程中对婴儿加 强保护，阻断传播途径，是目前可行的有效措施。控制和降低病毒性肝炎的母婴间传播，有利优生 优育，提高人口素质的基本国策。”

Study on Superinfection of HBV and HCV between Mother and Infant

Sera from 210 puerperants and new born' s umbilical cord were detected for marks of HBV and HCV by molecular and immunological techniques (PCR,RT-PCR and ELISA). The results ate: 65. 5 % babies are positive with marks while mothers are HBsAg( ), 81. 8% babies positive while mothers HBeAg( ), 75% babies positive while mothers Anti-HCV( ), 100% babies are positive while mothers both HBV-RNA( ) and HCV-RNA( ). It is shown that vertical transmission of HBV/HCV or both viruses exists between mother and baby. Vertical transmission may occur in ulterus and during perinatal period. This is the main infection way for baby virus hepatitis. Diagnosis can not be made by symptoms,which are not specific. So sensitive and specific detection methods must be established to provide early diagnosing evidences. Perinatal health care intensive care for baby during parturition,and blocking the route of transmission are effective precautionary measures. Controlling and reducing virus hepatitis transmission between mother and baby is advantegeous to the basic national policy of aristogenesis and excellent infanticulture and improving population quality.