| ER、PR、C-erbB-2在子宫内膜癌中的表达及临床意义 |
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| 引用本文： | 姚安梅,袁渊,杨雪梅,王晓敏,王平.ER、PR、C-erbB-2在子宫内膜癌中的表达及临床意义[J].陕西医学杂志,2013,42(3):309-311. |
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| 作者姓名： | 姚安梅 袁渊 杨雪梅 王晓敏 王平 |
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| 作者单位： | 陕西省肿瘤医院妇瘤科,西安,710061 |
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| 摘 要： | 目的:探讨ER、PR、C-erbB-2在子宫内膜癌中的表达及意义。方法:应用免疫组化SP法检测三种基因蛋白在75例子宫内膜癌组织中的表达情况。结果:在子宫内膜癌组织中ER、PR、C-erbB-2阳性表达率分别为77.3%、72.0%、12.0%;ER、PR的表达与手术分期、病理分级及肌层浸润深度有关;C-erbB-2的表达与子宫内膜癌的病理类型、病理分级、手术病理分期、淋巴结转移有显著的统计学意义;ER、PR、C-erbB-2蛋白的阳性表达与预后有关。结论:ER、PR、C-erbB-2的检测对评价子宫内膜癌的生物学行为及预后有一定意义。
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| 关 键 词： | 子宫内膜癌/病理学 雌激素受体 @孕激素受体 C-erbB-2 免疫组织化学 |
The expressions and significance of ER,PR and C-erbB-2 in endometrial carcinoma |
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| Abstract: | Objective:To study the expressions and significance of ER,PR and C-erbB-2 in endometrial carcinoma.Methods:ER,PR and C-erbB-2 protein were examined by immunohistochemical SP method respectively in 75 cases of endometrial carcinoma.Results:The positive expression rates of ER,PR and C-erbB-2 were77.3%,72.0%,12.0% in endometrial carcinoma respectively.The expressions of ER and PR were related to operation stage,pathological grade and depth of myometrial invasion.C-erbB-2 were related to pathological type,pathological grade,operation stage and lymph node metastases.The positive expressions of ER,PR and C-erbB-2 were related to prognosis of endometrial carcinoma.Conclusion: The detections for ER,PR and C-erbB-2 have significances for evaluating biological behaviors and prognosis of endometrial carcinoma. |
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| Keywords: | Endometrial neoplasms/pathology Estrogen receptor @Progesterone receptor C-erbB-2 Immunohistochemistry |
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