Skin-tumour promoting activity of methyl ethyl ketone peroxide—a potent lipid-peroxidizing agent |
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| Authors: | MK Logani CP Sambuco PD Forbes RE Davies |
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| Affiliation: | The Skin and Cancer Hospital, Center for Photobiology, Temple University Health Sciences Center, 3322 North Broad Street, Philadelphia, PA 19140, USA |
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| Abstract: | The tumour-promoting activity of methyl ethyl ketone peroxide (MEKP) was tested on the skin of hairless mice using a two-stage initiation-promotion protocol. When ultraviolet radiation in the UVB region (280–320 nm) was used as tumour initiator, MEKP showed weak promoting activity. The promotional activity of MEKP was potentiated by diethyl maleate, which is known to deplete intracellular glutathione, suggesting that lipid peroxidation may be important in the tumour promotion. |
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| Keywords: | DEM = Diethyl maleate DBP = dibutyl phthalate MEKP = methyl ethyl ketone peroxide |
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