人精液源性病毒感染增强因子研究进展

人精液前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)多肽片段形成的淀粉样原纤维具有促进人类免疫缺陷病毒(human immunedeficiency virus,HIV)感染的作用,这些原纤维被称为精液源性病毒感染增强因子(semen-derived enhancer of viral infection,SEVI),其中PAP第248-286位多肽片段(PAP248-286)促进HIV感染的作用最强.具有阳离子特性的SEVI可通过静电作用捕获HIV颗粒而促进HIV感染.近期研究报道,SEVI对异嗜性小鼠白血病病毒相关病毒感染也有增强作用,可能与前列腺癌发生有关.某些多聚阴离子化合物和绿茶多酚成分能明显抑制SEVI活性.研究SEVI生物学特性及其功能对于HIV等病毒感染的防治具有重要意义.

Progress in the research of human semen-derived enhancer of viral infection

Amyloid fibrils formed by the peptides of prostatic acid phosphatase (PAP) in human semen proves to enhance human immunodeficiency virus (HIV) infection, and these fibrils are termed semen-derived enhancer of viral infection (SEVI). The peptide fragments containing 248 to 286 amino acid residues of PAP (PAP248-286) in SEVI are most effective to enhance HIV infection. SEVI with cationic properties can directly bind to HIV particles through electrostatic interactions, thus increasing HIV infection. Recently, it is reported that SEVI also boosts xenotropic murine leukemia virus-related virus infection which may be associated with prostate cancer. Some of the polyanionic compounds and the main green tea polyphenol can inhibit SEVI activity obviously. Study on the biological properties and effects of SEVI should be of great significance for prevention and treatment of HIV and other viral infections.