慢性乙型肝炎患者外周血单个核细胞内HBV-DNA与中医证型关系的研究 |
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引用本文: | 宓余强,郑淑文,张弘,梁树人,李顺天,曹武奎.慢性乙型肝炎患者外周血单个核细胞内HBV-DNA与中医证型关系的研究[J].中国中西医结合杂志,2007,27(4):296-299. |
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作者姓名: | 宓余强 郑淑文 张弘 梁树人 李顺天 曹武奎 |
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作者单位: | 天津市传染病医院,天津,300192 |
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基金项目: | 天津市卫生局中医中西医结合项目 |
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摘 要: | 目的探讨慢性乙型肝炎患者血清乙肝病毒脱氧核糖核酸(HBV—DNA)及外周血单个核细胞(PBMCs)中HBV.DNA感染与中医证型的关系。方法220例慢性乙型肝炎患者进行乙肝标志物检查、血清HBV—DNA(定量)及PBMCs中HBV—DNA检测(PCR方法),经中医辨证确定205例患者的中医证型。结果研究发现各中医证型血清HBV—DNA(定量)≥1.0×10^5拷贝/mL(高病毒栽量)患者比例由小到大排列依次为:湿热中阻证〈瘀血阻络证〈肝肾阴虚证〈脾肾阳虚证〈肝郁脾虚证。肝郁脾虚证组血清HBV—DNA(定量)≥1.0×10^5拷贝/mL患者比例最高(占82.5%),与湿热中阻证组(占55.2%)差异有显著性(P〈0.01)。各中医证型PBMCs中HBV—DNA感染患者比例由小到大排列依次为:肝肾阴虚证〈湿热中阻证〈脾肾阳虚证〈瘀血阻络证〈肝郁脾虚证。肝郁脾虚证组PBMCs中HBV.DNA感染患者比例最高(占77.2%),与肝肾阴虚证(占27.3%)、湿热中阻证(占34.3%)、瘀血阻络证(占53.1%)比较,差异均有显著性(P〈0.01)。结论血清HBV—DNA(定量)及PBMCs中HBV—DNA感染与中医证型之间有一定关系,肝郁脾虚证组血清HBV.DNA(定量)≥1.0×10^5拷贝/mL患者比例及PBMCs中HBV—DNA感染患者比例最高,治疗应注重扶正祛邪。
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关 键 词: | 慢性乙型肝炎 中医证型 外周血单个核细胞 乙肝病毒脱氧核糖核酸 |
收稿时间: | 2006-10-11 |
修稿时间: | 2006-12-25 |
Relationship between HBV-DNA in Peripheral Blood Mononuclear Cells and Syndrome Types of TCM in Chronic Hepatitis B Patients |
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Authors: | MI Yu-qiang ZHENG Shu-wen ZHANG Hong |
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Abstract: | OBJECTIVE: To study the relationship between TCM syndrome type and HBV-DNA in serum and peripheral blood mononuclear cells (PBMCs) in chronic hepatitis B (CHB) patients. METHODS: The serum HBV markers,HBV-DNA levels in serum and PBMCs, were quantitatively detected in 220 CHB patients by PCR method, and TCM syndrome type of 205 patients were differentiated. RESULTS: Arranged from low to high, the percentages of CHB patients with the serum HBV-DNA > or = 1.0 x l0(5) copy/mL (high viral loading) in the five syndrome types were as follows: damp-heat retention in middle-jiao syndrome (DHRS, 55.2%), blood stasis blocking collateral syndrome (BSBC), Gan-Shen yin deficiency syndrome (GSYS), Pi-Shen yang deficiency syndrome (PSDS) and Gan stagnation with Pi deficiency syndrome (GSPS, 82.5%), the difference was significant between DHRS and GSPS; those with HBV-DNA in PBMCs infection were: GSYS (27.3%), DHRS (34.3%), BSBC (53.1%) and GSPS (77.2%). The percentage in GSPS was the highest, which was significantly different to that in other syndromes. CONCLUSION: Amount of serum HBV-DNA and PBMCs HBV-DNA infection has certain correlation with the TCM syndrome type of CHB. The highest percentage of patients with HBV-DNA > or = 1.0 x l0(5) copy/mL and PBMCs HBV-DNA infection presented in CHB patients of GSPS type. We should pay more attention to strengthen genuine qi to eliminate pathogenic factors in treatment of CHB. |
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Keywords: | chronic hepatitis B TCM syndrome type peripheral blood mononuclear cells HBV-DNA |
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