| Nampt/Visfatin/PBEF研究进展 |
| |
| 引用本文： | 盛飞凤,刘昭前.Nampt/Visfatin/PBEF研究进展[J].中国临床药理学与治疗学,2009,14(12). |
| |
| 作者姓名： | 盛飞凤 刘昭前 |
| |
| 作者单位： | 中南大学临床药理研究所,遗传药理学湖南省重点实验室,长沙,410078,湖南 |
| |
| 摘 要： | 尼克酰胺磷酸核糖转移酶(nicotinamide phosphoribosyltransferase,Nampt)是生物合成NAD的关键限速酶,又被称为前B细胞克隆增强因子(pre-B cell colony enhancing factor,PBEF)和内脏脂肪素(visfatin).最近研究发现,Nampt/Visfatin/PBEF在NAD生物合成、代谢、炎症反应和细胞增殖、分化、凋亡等诸多领域发挥作用,可能影响2型糖尿病、急性肺损伤、恶性肿瘤等疾病发生、发展和预后.本文主要对Nampt/Visfatin/PBEF的生理功能及临床意义进行综述.
|
| 关 键 词： | 烟酰胺磷酸核糖转移酶 前B细胞克隆增强因子 内脏脂肪素 |
Research progress of Nampt/Visfatin/PBEF |
| |
| SHENG Fei-feng,HU Zhao-qian.Research progress of Nampt/Visfatin/PBEF[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2009,14(12). |
| |
| Authors: | SHENG Fei-feng HU Zhao-qian |
| |
| Abstract: | Nicotinamide phosphoribosyhransferase (Nampt)is the crucial rate-limiting enzyme of NAD biosynthesis.also known as pre-B eell colony-enhancing factor(PBEF)and visfatin.Recently,it has been found that Nampt/Visfatin/PBEF plays a role in many fields like NAD biosynthesis.metabolism and inflammatory response,as well as cell proliferation,differentiation and apoptosis.Nampt/Visfatin/PBEF might affeet the development and prognosis of diseases such as type 2 diabetes,pulmonary diseases,malignant tumors and so on.This paper focuses on the physiological function and clinical significance of Nampt/Visfatin/PBEF. |
| |
| Keywords: | nicotinamide phosphoribosyltransferase pre-B cell colony enhancing factor visfatin |
| 本文献已被 万方数据 等数据库收录！ |
|
