肝硬化患者凝血四项及D-二聚体检测的临床意义

目的探讨肝硬化患者凝血四项及D-二聚体检测的临床应用价值。方法对我院95例肝硬化患者（肝硬化代偿组51例,肝硬化失代偿组44例）及65例正常对照组进行凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FBG）浓度、凝血酶时间（TT）及D-二聚体含量的检测,并进行对比分析。结果与正常对照组相比,肝硬化组PT、APTT、TT明显延长（P〈0.05）,FBG明显降低（P〈0.05）,D-二聚体含量明显升高（P〈0.05）。与肝硬化代偿组相比,肝硬化失代偿组PT、APTT、TT明显延长（P〈0.05）,FBG明显降低（P〈0.05）,D-二聚体含量明显升高（P〈0.05）。结论凝血四项及D-二聚体的联合检测对肝硬化患者病情的判断、治疗和预防出血有重要意义。

Clinical significance of four coagulation tests and the D-dimer test in patients with liver cirrhosist

Objective To investigate the value of clinical applications of four coagulation tests and the D-dimer test in patients with liver cirrhosis.Methods 95 cases of liver cirrhosis（51 cases in compensated cirrhosis group and 44 cases in decompensated cirrhosis group） and 65 healthy people in control group underwent determinations of the prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen concentration（FBG）,thrombin time（TT） and the levels of D-dimer in our hospital.The results were compared and analyzed.Results Compared with the control group,PT,APTT and TT in the cirrhosis group were significantly prolonged（P0.05）,FBG was significantly lower（P0.05） and the levels of D-dimer were significantly higher（P0.05）;Compared with the compensated cirrhosis group,PT,APTT and TT in the decompensated cirrhosis group were significantly prolonged（P0.05）,FBG were significantly lower（P0.05）,and the levels of D-dimer were significantly higher（P0.05）.Conclusion The combined determination of four coagulation tests and the D-dimer are clinically significant to the judgment of disease conditions,the treatment and the prevention of hemorrhage in patient with liver cirrhosis.