| 5-(2,3-二氯苯氧基)-4-氯-2-硝基苯胺合成工艺的研究 |
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| 引用本文： | 崔志芹,王志祥.5-(2,3-二氯苯氧基)-4-氯-2-硝基苯胺合成工艺的研究[J].化工时刊,2006,20(8):24-26. |
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| 作者姓名： | 崔志芹 王志祥 |
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| 作者单位： | 中国药科大学药学院,江苏,南京,210009 |
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| 摘 要： | 研究了以2,3-二氯苯酚和4,5-二氯-2-硝基苯胺通过缩合反应制备5-(2,3-二氯苯氧基)-4-氯-2-硝基苯胺的合成工艺。着重考察了催化剂、反应时间、加料速率、加料顺序等因素对缩合反应的影响。结果表明,不同催化剂对反应选择性的影响很大,采用适宜的催化剂可有效抑制副反应的发生,选择性可达95%。转化率随时间的延长而逐渐增加,反应选择性随时间的延长慢慢下降,反应时间宜控制在8 h左右,收率可达88%。
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| 关 键 词： | 2 3-二氯苯酚4 5-二氯-2-硝基苯胺三氯苯哒唑 |
| 收稿时间： | 2006-05-31 |
| 修稿时间： | 2006年5月31日 |
Synthesis conditions for 5-(2,3-dichlorophenoxy)-4-chloro-2-nitrobenzenamine |
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| Cui Zhiqin,Wang Zhixiang.Synthesis conditions for 5-(2,3-dichlorophenoxy)-4-chloro-2-nitrobenzenamine[J].Chemical Industry Times,2006,20(8):24-26. |
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| Authors: | Cui Zhiqin Wang Zhixiang |
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| Affiliation: | College of Pharmaceutics, China Pharmaceutical University, Jiangsu Nanjing 210009 |
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| Abstract: | 5-(2,3-dichlorophenoxy)-4-chloro-2-nitrobenzenamine,an important intermediate of triclabendazole was synthesized by using 2,3-dichlorophenol and 4,5-dichloro-2-nitrobenzenamine.Influences of catalysts,reaction time,the sequence and velocity of adding materials were observed.Selectivity was significant affected by the kind of catalysts.Selectivity was 95% if the suitable catalyst was used.The conversion rate increased and selectivity decreased with time going on.Yield reached 88% when reaction time was 8 hours and decreased after that.The by-reaction increased in alkaline environment. |
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| Keywords: | 2 3-dichlorophenol 4 5-dichloro-2-nitrobenzenamine triclabendazole |
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