| 吉西他滨联合顺铂治疗晚期非小细胞肺癌临床观察 |
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| 引用本文： | 吴标,庄武.吉西他滨联合顺铂治疗晚期非小细胞肺癌临床观察[J].海峡药学,2005,17(1):67-68. |
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| 作者姓名： | 吴标 庄武 |
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| 作者单位： | 福建省肿瘤医院内科,福州,350014;福建省肿瘤医院内科,福州,350014 |
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| 摘 要： | 目的观察吉西他滨联合顺铂治疗晚期非小细胞肺癌的近期疗效及毒副反应。方法吉西他滨1．2／m^2，第一、八天；顺铂25mg／m^2，第二～四天，21天为1周期，两周期以上评价疗效。结果可评价疗效43例，其中CR1例，PR19例，NC20例，PD3例，总有效率CR PR46．5％。主要毒副反应为骨髓抑制、恶心、呕吐。结论吉西他滨联合DDP治疗晚期非小细胞肺癌疗效高，毒副反应轻，可以作为治疗晚期非小细胞肺癌的一线治疗方案。
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| 关 键 词： | 肺肿瘤 吉西他滨 顺铂 化疗 |
| 文章编号： | 1006-3765(2005)01-0067-02 |
Clinical Study on the Treatment of Advanced Non-Small-cell Lung Cancer with Gemcitabine Plus Cisplatin |
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| WU Biao,ZHUANG Wu.Clinical Study on the Treatment of Advanced Non-Small-cell Lung Cancer with Gemcitabine Plus Cisplatin[J].Strait Pharmaceutical Journal,2005,17(1):67-68. |
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| Authors: | WU Biao ZHUANG Wu |
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| Abstract: | OBJECTIVE To evaluate the efficacy, toxicity and side effects of gemcitabine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer(NSCLC). METHODS The patient with advanced NSCLC were treated with gemcitabine plus cisplatin. Gemcitabine was given at a dose of 1.2/ m 2 on days1 and 8, Cisplatin 25mg/ m 2 on day 2 to 4. The schedule was repeated every 21 days ,with at least two cycles.RESULTS 43 of all the cases could be evaluated. CR 1 case ,PR 19 case, NC 20 case , PD 3 case ,the overall response rate was 46.5%(CR+PR). The main toxicity and side effects were myelosuppression, nausea, vomiting.CONCLUSION Gemcitabine plus cisplatin is safe and effective therapy for patient with advanced Non-small-cell-lung cancer. |
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| Keywords: | Lung neoplasm Gemcitabine Cisplatin Chemotherapy |
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