骨髓间充质干细胞移植改善心肌功能机制的研究与进展

背景：骨髓间充质干细胞移植可以通过影响心肌细胞形成和心肌血管再生，改善心脏结构的重构和心功能。 目的：通过对骨髓间充质干细胞移植改善心肌功能机制的研究来初步阐述骨髓间充质干细胞移植临床治疗缺血性心脏病理论依据。 方法：电子检索中国生物医学文献数据库和计算机Medline数据库1994年至2011年收录的关于干细胞在缺血性心脏疾病中应用的相关综述和论文报告，并分析其研究进展。 结果与结论：共纳入相关文献37篇。骨髓干细胞移植自体应用时无免疫排斥反应，可在体外大量扩增，避免伦理争论。骨髓干细胞治疗心肌梗死的研究仍处于初期阶段，随着研究深入，如果找到临床应用有效、安全的剂量，其必将为防治缺血性心脏病提供全新的治疗手段。

Research advances in mechanisms by which bone marrow stem cells improve myocardial function

BACKGROUND:Bone marrow mesenchymal stem cells transplantation can significantly improve the cardiac structure reconfiguration and cardiac function through affecting the myocardial cell formation and myocardial angiogenesis. OBJECTIVE:To summarize the theoretical basis of bone marrow mesenchymal stem cells transplantation for the treatment of ischemic cardomyopathy through researching the effect of bone marrow mesenchymal stem cells transplantation on myocardial function. METHODS:The Chinese Biomedical Literature database and Medline database from 1994 to 2011 were used to search the reviews and reports that relate to the application of bone marrow mesenchymal stem cells transplantation for the treatment of ischemic cardomyopathy, and the research progress was analyzed. RESULTS AND CONCLUSION:A total of 37 articles were included for the review. Autologous application of bone marrow mesenchmal stem cells transplantation can be amplified in vitro without immune rejection and can avoid the ethical controversy. Research of bone marrow stem cells for the treatment of acute myocardial infarction is still in the early stage. With the development of the research, bone marrow mesenchymal stem cells become a new method for the treatment of ischemic cardiomyopathy if we can find an effective and safe dosage.