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酮咯酸新型制剂的研究进展
引用本文:徐晓勇,马凤森,黄颖聪.酮咯酸新型制剂的研究进展[J].现代药物与临床,2016,31(1):116-121.
作者姓名:徐晓勇  马凤森  黄颖聪
作者单位:1. 浙江工业大学药学院,浙江杭州,310014;2. 浙江工业大学药学院,浙江杭州310014;浙江中医药大学第三临床医学院,浙江杭州310009
基金项目:浙江省重点科技创新团队计划资助项目(2013TD15)
摘    要:酮咯酸是一种新一代强效镇痛的非甾体类抗炎药.随着给药系统和制剂技术的不断发展,酮咯酸除常规的口服与注射给药外,还开发了经皮肤、眼部、鼻腔及口腔黏膜的给药新途径与新剂型,使酮咯酸具有长效镇痛和局部给药局部起效两大主要特点.酮咯酸新型制剂镇痛效果良好,且能提高患者的顺应性和用药安全性,具有良好的市场前景.

关 键 词:酮咯酸  长效镇痛  局部给药  制剂开发
收稿时间:2015/11/23 0:00:00

Progress research on novel formulation of ketorolac
XU Xiao-yong,MA Feng-sen and HUANG Ying-cong.Progress research on novel formulation of ketorolac[J].Drugs & Clinic,2016,31(1):116-121.
Authors:XU Xiao-yong  MA Feng-sen and HUANG Ying-cong
Affiliation:College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China;College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China;The Third Clinical College, Zhejiang Chinese Medical University, Hangzhou 310009, China;College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China
Abstract:Ketorolac is a new kind of non steroidal agents with potent analgesic activities. New formulation and delivery systems of ketorolac has been developed such as ocular, transdermal, nasal and buccal delivery systems in addition to oral and injection dosage forms, which makes the formulation of ketorolac long-lasting and local effect. The new ketorolac formulations have good analgesic effect, and are objective to improving patient's compliance and security, which have a promising future.
Keywords:ketorolac  long-lasting nalgesia  local drug delivery  formulation development
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