重型乙型肝炎血清可溶性白细胞介素2受体及外周血T淋巴细胞亚群的相关性

对２１例重型乙型肝炎患者白细胞介素２受体（ｓＩＬ－２Ｒ）及Ｔ淋巴细胞亚群检测发现，急性及亚急性重型、慢性重型肝炎患者的ｓＩＬ－２Ｒ均显著增高，与正常对照比较，Ｐ＜０００１。急性、亚急性重型及慢性重型乙型肝炎患者的ＣＤ＋４明显降低，ＣＤ＋８则显著升高，与对照组比较，Ｐ均＜００１。检测证实ｓＩＬ－２Ｒ增高与活化的ＣＤ＋８具有相关性，表明活化的ＣＤ＋８细胞主要是细胞毒性Ｔ细胞（ＣＴＬ），其在急性和亚急性重型肝炎发病中可能起重要作用。ＣＤ＋４、ＣＤ＋８细胞在急性和慢性重型乙肝中表达的不同，提示二者发病机制不同。

Study on relationship of soluble Interleukin-2 receptors in serious hepatitis B patients and the T lymphocyte subgroup

The assay of sIL-2R and T lymphocyte subgroup in 21 cases of serious HB patients revealed that serum sIL-2R in patients of acute and subacute or chronic serious HB was significantly higher than those in normal controls, P<0.001, but the CD 4 lymphocytes in all these patients obviously decreased and CD 8 lymphocytes notably increased when comppared with that in normal group, P<0.01. The results showed that increasing of sIL-2R is associated with the activation of CD 8 cells which is mainly of cytotoxicity T lymphoeytes that play an important role in the pathogenesis of acute and subacute serious HB. The different expression of CD 4 and CD 8 in acute and chronic serious HB suggests a different pathogenetic mechanism between them.