三维适形放疗联合肝动脉化疗栓塞治疗原发性肝癌的疗效

目的 探讨肝动脉化疗栓塞（TACE）联合三维适形放射治疗（3D-CRT）治疗不能手术切除的原发性肝癌（PHC）的效果.方法 PHC患者80例,分为TACE治疗（对照组）40例和3D-CRT＋TACE治疗（观察组）40例;观察疗效及生存率.结果 观察组有效35例（87.5%）,高于对照组的28例（70.0%）（x2=3.89,P＜0.05）;观察组1、2、3年的生存率分别为67.5%、55.5%、40.0%,均高于对照组50.0%、27.5%、15.0%（x2=3.4576,x2=3.726,x2=3.635,均P＜0.05）;两组不良反应发生率差异无统计学意义（P＞0.05）.结论 三维适形放疗联合肝动脉化疗栓塞对不能手术切除的PHC具有较好的疗效,且不良反应可以耐受.

Efficacy of three dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization on primary hepatocellular carcinoma

Objective To evaluate the effect of hepatic arterial chemo-embolization( TACE) combined threedimensional conformal radiation therapy (3 D-CRT) in treatment of un- resectable primary hepatocellular cancer (PHC). Methods 80 patients with PHC were divided into TACE therapy(control group) 40 cases and 3D-CRT + TACE treatment( observation group)40 cases,The efficacy and survival rate was observed. Results The rate of effect in observation group were 35 cases (87. 5% ) higher than that 28 cases (70. 0% ) in control group ( x2 = 3. 89, P < 0.05 ) ,The rate of survival in observation group of 1、2、3-year were 67. 5% ,55. 5% ,40. 0% which were higher than that 50. 0% ,27. 5% ,15. 0% in control group( x2 = 3.4576, x2= 3.726, x2 = 3. 635, all P < 0.05), The incidence of adverse reactions in two groups had no significant difference ( P <0.05). Conclusion The three-dimensional conformal radiotherapy combined with transcatheter arterial chemoem-bolization for unresectable primary hepatocellular cancer had a better efficacy,and adverse reactions could be tolerated.