| 恩替卡韦联合地塞米松治疗慢性重型乙型肝炎临床研究 |
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| 引用本文： | 牛龙喜,郭俊岗,刘旭玲,刘淑珍,师雁媛,刘长凯. 恩替卡韦联合地塞米松治疗慢性重型乙型肝炎临床研究[J]. 中原医刊, 2011, 0(9): 8-9 |
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| 作者姓名： | 牛龙喜 郭俊岗 刘旭玲 刘淑珍 师雁媛 刘长凯 |
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| 作者单位： | 山西省大同市第四人民医院,037008 |
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| 摘 要： | 目的探讨恩替卡韦联合地塞米松治疗慢性重型乙型肝炎的疗效。方法将128例慢性重型乙型肝炎患者随机分为治疗组64例，对照组64例，两组均给予同样的综合治疗，治疗组增加恩替卡韦和地塞米松治疗。结果治疗组血清HBV—DNA转阴率为91．5％（P〈0．01），丙氨酸氨基转移酶、血清总胆红素恢复正常率为67．2％、62．5％，总有效率为85．9％，病死率为14．1％，明显优于对照组（P〈0．05）。结论恩替卡韦联合地塞米松治疗慢性重型乙型肝炎疗效佳。
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| 关 键 词： | 慢性重型乙型肝炎 恩替卡韦 地塞米松 |
Clinical study of entecavir combined with dexamethasone for treatment of chronic severe hepatitis B |
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| NIU Long-xi,GUO Jun-gang,LIU Xu-ling,LIU Shu-zhen,SHI Yan-yuan,LIU Chang-kai. Clinical study of entecavir combined with dexamethasone for treatment of chronic severe hepatitis B[J]. Central Plains Medical Journal, 2011, 0(9): 8-9 |
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| Authors: | NIU Long-xi GUO Jun-gang LIU Xu-ling LIU Shu-zhen SHI Yan-yuan LIU Chang-kai |
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| Affiliation: | (The fourth People＇ s Hospital of Datong, Datong 037008, China) |
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| Abstract: | Objective To investigate the effect of entecavir combined with dexamethasone treatment on chronic severe hepatitis. Methods One hundred and twenty -eight patients with chronic severe hepatitis B were randomly divided into treatment group （64 patients） and control group （64 patients）, two groups were given the same comprehensive treatment, the treatment group received entecavir and dexam- ethasone in addition. Results The serum HBV - DNA negative rate was 91.5 % （ P 〈 0.01 ） in treatment group, the ALT, TBIL normal rate were 67.2%, 62.5%, total effective rate was 85.9%, mortality was 14.1% in treatment group, which were significantly better than control group（ P 〈0.05）. Conclusions Entecavir combined with dexamethasone treatment for chronic severe hepatitis B has good effect. |
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| Keywords: | Chronic severe hepatitis B Entecavir Dexamethasone |
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