| 毛叶香茶菜抗癌成分的研究——Ⅰ.毛叶香茶菜素A和B的结构 |
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| 引用本文： | 李继成,刘晨江,安新宗,汪茂田,赵天增,余守志,赵根锁,陈荣峰.毛叶香茶菜抗癌成分的研究——Ⅰ.毛叶香茶菜素A和B的结构[J].药学学报,1982,17(9):682-687. |
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| 作者姓名： | 李继成 刘晨江 安新宗 汪茂田 赵天增 余守志 赵根锁 陈荣峰 |
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| 作者单位： | 河南医学科学研究所 郑州
(李继成，刘晨江，安新宗)，河南化学研究所 郑州
(汪茂田，赵天增，余守志，赵根锁)，河南化学研究所 郑州(陈荣峰) |
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| 摘 要： | 自毛叶香茶菜Rabdosia japonica(Burm.f)Hara的干叶中分离出四个二萜化合物,其中两个是新的二萜,命名为毛叶香茶菜素A和B。通过光谱分析和化学反应转变成已知化合物epinodosin 6和isodonal 8确定了毛叶香茶菜素A和B的结构分别为3和7。初步的抗癌试验表明,3和7都具有明显细胞毒作用。其它两个二萜成分证明为enmenol 4和epinodosinol 5。
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| 关 键 词： | 毛叶香茶菜 毛叶香茶菜素A 毛叶香茶菜素B enmenol epinodosinol |
| 收稿时间： | 1981-06-20 |
STUDIES ON THE ANTITUMOR CONSTITUENT OF RABDOSIA JAPONICA (BURM. F) HARA. THE STRUCTURES OF RABDOSIN A AND B |
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| LI Ji-cheng,LIU Chen-jiang,AN Xin-zong,WANG,Mao-tian,ZHAO Tian-zeng,YU Shou-zhi,ZHAO Gen-suo and CHEN Rong-feng.STUDIES ON THE ANTITUMOR CONSTITUENT OF RABDOSIA JAPONICA (BURM. F) HARA. THE STRUCTURES OF RABDOSIN A AND B[J].Acta Pharmaceutica Sinica,1982,17(9):682-687. |
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| Authors: | LI Ji-cheng LIU Chen-jiang AN Xin-zong WANG Mao-tian ZHAO Tian-zeng YU Shou-zhi ZHAO Gen-suo and CHEN Rong-feng |
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| Abstract: | Four diterpenoids were isolated from the dried leaves of Rabdosia japonica (Burm.f) Hara. Two new diterpenoids were named as rabdosin A and B. Spectroscopic investigation and chemical conversion into epinodosin(6) and isodonal(8) established the structures of rabdosin A and B as(3) and(7)respectively. Antitumor activity has been tested preliminarily, both (3) and (7) showed significant cytotoxicity. The other two diterpenoids were shown to be identical with the known enmenol (4) and peinodosinol(5). |
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| Keywords: | Rabdosia japonica (Burm f) Rabdosin A Rabdosin B Epinodosinol Enmenol |
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