| 4-氯-8-甲氧基喹啉的合成 |
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| 引用本文： | 孔建,刘丹,朱秀杰,姜家妹.4-氯-8-甲氧基喹啉的合成[J].精细化工中间体,2010,40(5):32-33,36. |
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| 作者姓名： | 孔建 刘丹 朱秀杰 姜家妹 |
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| 作者单位： | 沈阳化工大学制药工程教研室,辽宁沈阳110142 |
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| 摘 要： | 以2-甲氧基苯胺与乙氧基亚甲基丙二酸二乙酯为起始原料,经缩合、环合、水解、脱羧、氯化反应制得目标化合物4-氯-8-甲氧基喹啉,总收率为33.81%(以2-甲氧基苯胺计,m/m)。对各步合成工艺进行了优化,目标产物结构经1H NMR和MS确证。
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| 关 键 词： | 2-甲氧基苯胺 4-氯-8-甲氧基喹啉 合成 |
Synthesis of 4-Chloro-8-methoxyquinoline |
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| KONG Jian,LIU Dan,ZHU Xiu-jie,JIANG Jia-mei.Synthesis of 4-Chloro-8-methoxyquinoline[J].Fine Chemical Intermediates,2010,40(5):32-33,36. |
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| Authors: | KONG Jian LIU Dan ZHU Xiu-jie JIANG Jia-mei |
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| Affiliation: | (Faculty of Pharmaceutical Engineering,Shenyang University of Chemical Technology,Shenyang 110142,China) |
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| Abstract: | 4-Chloro-8-methoxyquinoline was synthesized from 2-anisidine and diethyl（ethoxymethylene） malonate via condensation,cyclization,hydrolysis,decarboxylation and chlorination in overall yield of 33.81%.The reaction conditions were optimized and product was confirmed by 1H NMR and MS. |
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| Keywords: | 2-anisidine 4-chloro-8-methoxyquinoline synthesis |
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