| 生理条件下的S期检查点 |
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| 引用本文： | 苏 华,杭海英.生理条件下的S期检查点[J].生物化学与生物物理进展,2006,33(2):122-126. |
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| 作者姓名： | 苏 华 杭海英 |
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| 作者单位： | 中国科学院生物物理研究所,北京,100101 |
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| 摘 要： | 细胞周期检查点在细胞遭遇DNA损伤因子的攻击或遇到营养缺乏等不利因素作用时,能够暂时阻止或减慢细胞周期的进程,是细胞在长期进化中发展起来的抵御DNA损伤的重要机制.不仅如此,最近的研究表明,在正常生理条件下,存在一种S期检查点,对DNA复制的速度进行调控.从分子水平而言,这种调控作用可能是通过一系列细胞周期调控蛋白如ATR、9-1-1复合体、Chk1、Cdc25A和CDK2等的作用来实现的.这种调节作用对细胞至关重要,它使DNA复制速度不致于过快,从而减少复制过程中发生错误的几率,维护基因组的稳定性.
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| 关 键 词： | 细胞周期检查点 DNA复制 调节机制 |
| 收稿时间： | 2005-08-01 |
| 修稿时间： | 2005-08-012005-09-30 |
Physiological S-phase Checkpoint |
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| SU Hua and HANG Hai-Ying.Physiological S-phase Checkpoint[J].Progress In Biochemistry and Biophysics,2006,33(2):122-126. |
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| Authors: | SU Hua and HANG Hai-Ying |
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| Affiliation: | Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | Cell cycle checkpoints are protective mechanism responding to DNA damages originated from externalor internal factors. When cells are exposed to genotoxic stress or when nutrition crisis occurs, cell cycleprogression is usually stopped or slowed down by cell cycle checkpoints to allow for DNA repair or for handlingthe crisis. Besides, recent studies suggest that some cell cycle checkpoint proteins are also involved in regulatingphysiological DNA replication via controlling the rate of DNA replication. Cell cycle checkpoint proteins ATR,9-1-1 complex, Chk1, Cdc25A and CDK2 may participate in this process. This kind of regulation is supposed to bevery important for ensuring accurate DNA replication and maintaining genomic stability. |
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| Keywords: | cell cycle checkpoint DNA replication regulation mechanism |
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