| 2-氨基-5-硝基噻唑的高收率合成工艺 |
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| 引用本文： | 吕星鑫,吕耀宏.2-氨基-5-硝基噻唑的高收率合成工艺[J].精细化工中间体,2012,42(5):29-31. |
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| 作者姓名： | 吕星鑫 吕耀宏 |
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| 作者单位： | 浙江理工大学理学院,浙江杭州,310018 |
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| 摘 要： | 2-氨基-5-硝基噻唑是医药和染料重要的合成中间体。以醋酸乙烯酯为原料,经过氯化、水解、环合以及硝化等过程合成目标产物。较优工艺条件为:n(醋酸乙烯酯)∶n(硫脲)=1∶1.0,环合温度50℃,硝化温度30℃。反应总收率提高到84%。产品经高效液相色谱、1H NMR表征。产品纯度97.5%(HPLC)。该方法具有成本低、收率高、易于工业化等优点。
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| 关 键 词： | 2-氨基-5-硝基噻唑 高收率 合成工艺 2-氨基噻唑 |
High Yield Process for the Preparation of 2-Amino-5-nitrothiazole |
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| L Xing-xin
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L Yao-hong.High Yield Process for the Preparation of 2-Amino-5-nitrothiazole[J].Fine Chemical Intermediates,2012,42(5):29-31. |
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| Authors: | L Xing-xin L Yao-hong |
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| Affiliation: | L(U) Xing-xin
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L(U) Yao-hong |
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| Abstract: | 2-Amino-5-nitrothiazole is an important intermediate for organic synthesis in the fields of medicine and dyes.This compound was synthesized in overall yield of 84% starting from vinyl acetate via chlorination,hydrolysis,cyclization and nitration.The optimal reaction conditions were as follows:the molar ratio of vinyl acetate to thiourea of 1 to 1,the cyclization temperature of 50℃,the nitration temperature of 30℃.The product was confirmed with 1H NMR and HPLC.Its purity was 97.5%(HPLC). |
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| Keywords: | 2-amino-5-nitrothiazole high yield preparation process 2-aminothiazole |
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