乳腺癌脑转移的管理与治疗#br# #br# #br#

乳腺癌进展中10％～15％的患者会发生脑转移。随着乳腺癌颅外转移病灶控制及患者生存期延长，脑转移的发生率将有所增加。目前，乳腺癌脑转移患者的治疗仍是一个临床难题，其预后极差。乳腺癌的分子分型直接影响患者脑转移的发生率、治疗手段及预后。目前乳腺癌脑转移的治疗手段，包括局部治疗与全身治疗。本文就乳腺癌分子分型与脑转移发生率、脑转移的分子机制及治疗手段进行了综述，旨在为乳腺癌脑转移患者的个体化诊疗与多学科管理提供新的思路。

Management and treatment strategies of breast cancer patients with brain metastasis#br# #br#

About 10％ 15％ of breast cancer patients have brain metastases. The incidence of brain metastases will continue to increase with prolonged survival and the control of extracranial metastases. Currently， brain metastases are still important clinical challenges and associated with extremely poor prognosis. The molecular subtypes of breast cancer directly affect the incidence of brain metastases， treatment options and prognosis of patients. The current treatment strategies include local therapy and systemic therapy. This article reviews the relationship between the molecular subtypes of breast cancer and the incidence and molecular mechanism of brain metastases and the treatment methods， aiming to improve the new ideas for the individualized diagnosis and treatment of breast cancer patients with brain metastases and multidisciplinary management.